Skip to Main content Skip to Navigation
Conference papers

New Targets for the treatment of mature B cell non Hodgkin lymphomas

Abstract : Whole exome sequencing (WES) by next generation sequencing (NGS) has completely redefined the genetic landscape of mature B‐cell non‐Hodgkin lymphomas (NHL) by identifying recurrent single nucleotide variants and providing new therapeutic opportunities. Some of these somatic mutation target genes that play a crucial role in B‐cell function (BCR signalling, NFκ‐B pathway, Toll‐like receptor signalling, and the PI3K pathway), immunity, cell cycle/apoptosis, or chromatin modification. Some driver mutations represent the Achilles Heel of the tumours and may be translated into therapeutic interventions. BCR signalling is targeted by inhibitors of the early components of the pathway, such as BTK, SYK, PKCβ, or PIK3δ, whereas the NF‐KB pathway is targeted by upstream and downstream inhibitors (proteasome/ubiquitin complex) or more pleiotropic agents (lenalidomide). In this review, following an overview of the somatic mutations reported in mature B‐cell malignancies, especially in diffuse large B‐cell lymphomas and Burkitt lymphomas in both adults and children, we focus on activating and clustered driver mutations targeting genes including MYD88, CD79A/B, EZH2, and CARD11 and discuss their clinical and therapeutic relevance in the precision medicine era.
Document type :
Conference papers
Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-02483479
Contributor : Elodie Bohers <>
Submitted on : Tuesday, February 18, 2020 - 4:53:56 PM
Last modification on : Wednesday, February 19, 2020 - 1:36:38 AM

Identifiers

  • HAL Id : hal-02483479, version 1

Citation

Fabrice Jardin. New Targets for the treatment of mature B cell non Hodgkin lymphomas. 13th International Conference on Malignant Lymphoma (ICML), Juin 2015, Lugano (Suisse), Jun 2015, Lugano, Switzerland. ⟨hal-02483479⟩

Share

Metrics

Record views

21