Study on daptomycin use and implementation of an antimicrobial stewardship program

Camille Castel (1) , Arnaud de La Blanchardière (2) , Jocelyn Michon (2) , Vincent Cattoir (3) , Guillaume Saint-Lorant (1, 4)

1 Service de Pharmacie [CHU Caen]
2 Unité de Maladies Infectieuses et Tropicales [CHU Caen]
3 Service de Microbiologie [CHU Caen]
4 ABTE - Aliments Bioprocédés Toxicologie Environnements

Background Treatment of Gram-positive pathogens remains a major health issue due to the presence of methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococcus spp. Daptomycin offers an alternative after therapeutic failure using glycopeptides. Yet its use requires strict control given its financial impact and environmental risks. Since 2014, the use of daptomycin within our hospital has intensified, occasionally outside the scope of its approved indications. Objectives: The aim of this study is to analyze the appropriateness of daptomycin prescriptions. Setting This work was conducted in a 1500-bed University Hospital. Method A descriptive retrospective study was conducted from November 2013 to July 2014.

Keywords: Endocarditis; Daptomycin; Bone and joint infection; Antimicrobial stewardship; France; Prescribing audit

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

Camille Castel, Arnaud de La Blanchardière, Jocelyn Michon, Vincent Cattoir, Guillaume Saint-Lorant. Study on daptomycin use and implementation of an antimicrobial stewardship program. International Journal of Clinical Pharmacy, 2016, 38 (2), pp.421-428. ⟨10.1007/s11096-016-0271-z⟩. ⟨hal-02470416⟩