8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker of oxidative damage in oesophageal cancer patients: lack of association with antioxidant vitamins and polymorphism of hOGG1 and GST

Stéphanie Lagadu , Mathilde Lechevrel (1, 2) , François Sichel (3, 1, 2) , Jean Breton (4) , Didier Pottier (1) , Rémy Couderc (5) , Fathi Moussa , Virginie Prevost (6)

1 GRECAN - Groupe Régional d'Etudes sur le CANcer
2 UNICAEN - Université de Caen Normandie
3 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
4 SCIB - UMR E3 - Service de Chimie Inorganique et Biologique
5 Service de Biochimie et de Biologie Moléculaire [CHU Trousseau]
6 ANTICIPE - Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers

The present report was designed to investigate the origins of elevated oxidative stress measured in cancer patients in our previous work related to a case-control study (17 cases, 43 controls) on oesophageal cancers. The aim was to characterize the relationship between the levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), antioxidant vitamins and genetic susceptibility.

Domains: Life Sciences [q-bio]; Biochemistry, Molecular Biology; Molecular biology; Life Sciences [q-bio]; Cancer; Life Sciences [q-bio]; Ecology, environment; Health; Life Sciences [q-bio]; Toxicology; Chemical Sciences; Analytical chemistry

Stéphanie Lagadu, Mathilde Lechevrel, François Sichel, Jean Breton, Didier Pottier, et al.. 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker of oxidative damage in oesophageal cancer patients: lack of association with antioxidant vitamins and polymorphism of hOGG1 and GST. Journal of experimental & clinical cancer research, 2010, 29 (1), pp.157. ⟨10.1186/1756-9966-29-157⟩. ⟨hal-02461268⟩