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The topological phase diagram of cimetidine: A case of overall monotropy

Abstract : Cimetidine is a histamine H2-receptor antagonist used against peptic ulcers. It is known to exhibit crystalline polymorphism. Forms A and D melt within 0.35 degrees from each other and the enthalpies of fusion are similar as well. The present paper demonstrates how to construct a pressure—temperature phase diagram with only calorimetric and volumetric data available. The phase diagram provides the stability domains and the phase equilibria for the phases A, D, the liquid and the vapor. Cimetidine is overall monotropic with form D the only stable solid phase.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02452411
Contributor : Ivo Rietveld <>
Submitted on : Thursday, January 23, 2020 - 2:39:04 PM
Last modification on : Friday, May 29, 2020 - 10:58:05 AM

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R. Ceolin, Ivo B. Rietveld. The topological phase diagram of cimetidine: A case of overall monotropy. Annales Pharmaceutiques Françaises, Elsevier Masson, 2017, 75 (2), pp.89-94. ⟨10.1016/j.pharma.2016.11.002⟩. ⟨hal-02452411⟩

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