Neonatal cerebral hypoxia-ischemia in mice triggers age-dependent vascular effects and disabilities in adults; implication of tissue plasminogen activator (tPA)

Nicolas Dupré (1, 2) , Arnaud Arabo (3) , Cyrille M Orset (4) , Julie Maucotel (5) , Yannick Detroussel , Michelle Hauchecorne (1, 2) , Bruno J. Gonzalez (2, 1) , Stéphane Marret (1, 2) , Denis Vivien (6) , Philippe Leroux (2, 1)

1 Neovasc - Team 4 NeoVasc - Region Team ERI 28 INSERM
2 GPMCND - Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques
3 UNIROUEN - Université de Rouen Normandie
4 Sérine protéases et physiopathologie de l'unité neurovasculaire
5 International Associated laboratory Samuel de Champlain
6 Cyceron - GIP Cyceron

Domains: Life Sciences [q-bio]

Nicolas Dupré, Arnaud Arabo, Cyrille M Orset, Julie Maucotel, Yannick Detroussel, et al.. Neonatal cerebral hypoxia-ischemia in mice triggers age-dependent vascular effects and disabilities in adults; implication of tissue plasminogen activator (tPA). Experimental Neurology, 2020, 323, pp.113087. ⟨10.1016/j.expneurol.2019.113087⟩. ⟨hal-02443823⟩