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Hadrontherapy Interactions in Molecular and Cellular Biology

Juliette Thariat 1, 2, 3 Samuel Valable 4, 2 Carine Laurent 2, 5 Siamak Haghdoost 2, 6, 7 Elodie Pérès 4, 2 Myriam Bernaudin 4, 2 François Sichel 2, 5 Paul Lesueur 1, 4, 2 Mathieu Césaire 2, 1 Edwige Petit 2, 4 Aurélie Ferré 2, 4 Yannick Saintigny 2, 6, 7 Sven Skog 8 Mihaela Tudor 7, 9, 10 Michael Gérard 2, 1 Sébastien Thureau 3, 11 Jean-Louis Habrand 2, 5, 1 Jacques Balosso 2, 1 François Chevalier 2, 6, 7
1 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
2 Advanced Resource Centre for HADrontherapy in Europe - ARCHADE
3 LPCC - Laboratoire de physique corpusculaire de Caen
4 ISTCT - Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales
5 ABTE - Aliments Bioprocédés Toxicologie Environnements
6 LARIA - Laboratoire d'Accueil et de Recherche avec les Ions Accélérés
DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/JACOB/IRCM
7 CIMAP - UMR 6252 - Centre de recherche sur les Ions, les MAtériaux et la Photonique
8 SSTK - Sino-Swed Molecular Bio-Medicine Research Institute
9 NIPNE - Horia Hulubei National Institute of Physics and Nuclear Engineering
10 University of Bucharest (ROMANIA)
11 CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen
Abstract : The resistance of cancer cells to radiotherapy is a major issue in the curative treatment of cancer patients. This resistance can be intrinsic or acquired after irradiation and has various definitions, depending on the endpoint that is chosen in assessing the response to radiation. This phenomenon might be strengthened by the radiosensitivity of surrounding healthy tissues. Sensitive organs near the tumor that is to be treated can be affected by direct irradiation or experience nontargeted reactions, leading to early or late effects that disrupt the quality of life of patients. For several decades, new modalities of irradiation that involve accelerated particles have been available, such as proton therapy and carbon therapy, raising the possibility of specifically targeting the tumor volume. The goal of this review is to examine the up-to-date radiobiological and clinical aspects of hadrontherapy, a discipline that is maturing, with promising applications. We first describe the physical and biological advantages of particles and their application in cancer treatment. The contribution of the microenvironment and surrounding healthy tissues to tumor radioresistance is then discussed, in relation to imaging and accurate visualization of potentially resistant hypoxic areas using dedicated markers, to identify patients and tumors that could benefit from hadrontherapy over conventional irradiation. Finally, we consider combined treatment strategies to improve the particle therapy of radioresistant cancers.
Keywords : hadrontherapy particle therapy radioresistance cancer hypoxia
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02429129
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Submitted on : Wednesday, July 8, 2020 - 2:50:28 PM
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ABTE | LPC-CAEN | ENSICAEN | UNICAEN | CNRS | CEA | IRAMIS-CIMAP | DSM-IRAMIS | IN2P3 | CEA-DRF | UNIROUEN | ISTCT-CERVOXY | COMUE-NORMANDIE | ISTCT | LPCC-AMI

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Juliette Thariat, Samuel Valable, Carine Laurent, Siamak Haghdoost, Elodie Pérès, et al.. Hadrontherapy Interactions in Molecular and Cellular Biology. International Journal of Molecular Sciences, MDPI, 2020, 21 (1), pp.133. ⟨10.3390/ijms21010133⟩. ⟨hal-02429129⟩

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