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Journal articles
Hadrontherapy Interactions in Molecular and Cellular Biology
Juliette Thariat
1, 2, 3
Samuel Valable
4, 2
Carine Laurent
2, 5
Siamak Haghdoost
2, 6, 7
Elodie Pérès
4, 2
Myriam Bernaudin
4, 2
François Sichel
2, 5
Paul Lesueur
1, 4, 2
Mathieu Césaire
2, 1
Edwige Petit
2, 4
Aurélie Ferré
2, 4
Yannick Saintigny
2, 6, 7
Sven Skog
8
Mihaela Tudor
7, 9, 10
Michael Gérard
2, 1
Sébastien Thureau
3, 11
Jean-Louis Habrand
2, 5, 1
Jacques Balosso
2, 1
François Chevalier
2, 6, 7
6
LARIA - Laboratoire d'Accueil et de Recherche avec les Ions Accélérés
DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/JACOB/IRCM
Juliette Thariat 1, 2, 3
Author
Samuel Valable 4, 2
Author IdHAL : samuel-valable ResearcherId : http://www.researcherid.com/rid/B-7578-2008 ORCID : https://orcid.org/0000-0003-0355-0270
Carine Laurent 2, 5
Author IdHAL : carine-laurent
Siamak Haghdoost 2, 6, 7
Author
Elodie A Pérès 4, 2
Author IdHAL : elodie-peres ResearcherId : http://www.researcherid.com/rid/AAC-6008-2019 ORCID : https://orcid.org/0000-0002-6687-1939
Myriam Bernaudin 4, 2
Author IdHAL : myriam-bernaudin ORCID : https://orcid.org/0000-0003-0778-3397
François Sichel 2, 5
Author IdHAL : francois-sichel ORCID : https://orcid.org/0000-0002-4094-7739
Paul Lesueur 1, 4, 2
Author
Mathieu Césaire 2, 1
Author
Edwige Petit 2, 4
Author
Aurélie Ferré 2, 4
Author IdHAL : aurelie-ferre
Yannick Saintigny 2, 6, 7
Author IdHAL : yannick-saintigny
Sven Skog 8
Author
Mihaela Tudor 7, 9, 10
Author
Michael Gérard 2, 1
Author
Sébastien Thureau 3, 11
Author
Jean-Louis Habrand 2, 5, 1
Author
Jacques Balosso 2, 1
Author
François Chevalier 2, 6, 7
Author IdHAL : francois-chevalier ORCID : https://orcid.org/0000-0002-8488-2324
1
UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (3 avenue général Harris, 14000 Caen - France)
- UNICANCER (101, rue de Tolbiac, 75654 Paris Cedex 13 - France)
- TCBN - Tumorothèque de Caen Basse-Normandie (3 avenue du Général Harris 14076 Caen cedex 5 - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
2
Advanced Resource Centre for HADrontherapy in Europe - ARCHADE (Caen - France)
3
LPCC - Laboratoire de physique corpusculaire de Caen (ENSICAEN - 6, boulevard du Marechal Juin 14050 Caen Cedex - France)
- UNICAEN - Université de Caen Normandie (Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5 - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- ENSICAEN - École Nationale Supérieure d'Ingénieurs de Caen (6, Boulevard du Maréchal Juin CS 45053 14050 CAEN cedex 04 - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6534 (France)
- IN2P3 - Institut National de Physique Nucléaire et de Physique des Particules du CNRS (France)
4
ISTCT - Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (GIP CYCERON Campus Jules Horowitz Bd Henri Becquerel BP 5229 14074 CAEN - France)
- UNICAEN - Université de Caen Normandie (Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5 - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 6030 (France)
5
ABTE - Aliments Bioprocédés Toxicologie Environnements (Campus 2
Boulevard Maréchal Juin
14032 Caen cedex - France)
- UNICAEN - Université de Caen Normandie : EA4651 (Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5 - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- UNIROUEN - Université de Rouen Normandie : EA4651 (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
6
LARIA - Laboratoire d'Accueil et de Recherche avec les Ions Accélérés (France)
- DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/JACOB/IRCM (Direction de Recherche Fondamentale
Fundamental Research Division
CEA Saclay
91191 Gif-sur-Yvette
- France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
7
CIMAP - UMR 6252 - Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252, 6, Boulevard du Maréchal Juin 14050 Caen cedex 4 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 6252 (France)
- ENSICAEN - École Nationale Supérieure d'Ingénieurs de Caen (6, Boulevard du Maréchal Juin CS 45053 14050 CAEN cedex 04 - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DRF/IRAMIS (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- UNICAEN - Université de Caen Normandie (Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5 - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
8
SSTK - Sino-Swed Molecular Bio-Medicine Research Institute (Shenzhen 518057, China - China)
9
NIPNE - Horia Hulubei National Institute of Physics and Nuclear Engineering (Str. Atomistilor no.407 P.O.BOX MG-6 76900 Bucharest - Magurele - Romania)
- IFIN-HH (France)
10
UniBuc - University of Bucharest (90, Panduri Street, Sector 5, 050663, Bucharest - Romania)
11
CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (Rue d'Amiens CS11516 76038 Rouen Cedex 1 - France)
Abstract : The resistance of cancer cells to radiotherapy is a major issue in the curative treatment of cancer patients. This resistance can be intrinsic or acquired after irradiation and has various definitions, depending on the endpoint that is chosen in assessing the response to radiation. This phenomenon might be strengthened by the radiosensitivity of surrounding healthy tissues. Sensitive organs near the tumor that is to be treated can be affected by direct irradiation or experience nontargeted reactions, leading to early or late effects that disrupt the quality of life of patients. For several decades, new modalities of irradiation that involve accelerated particles have been available, such as proton therapy and carbon therapy, raising the possibility of specifically targeting the tumor volume. The goal of this review is to examine the up-to-date radiobiological and clinical aspects of hadrontherapy, a discipline that is maturing, with promising applications. We first describe the physical and biological advantages of particles and their application in cancer treatment. The contribution of the microenvironment and surrounding healthy tissues to tumor radioresistance is then discussed, in relation to imaging and accurate visualization of potentially resistant hypoxic areas using dedicated markers, to identify patients and tumors that could benefit from hadrontherapy over conventional irradiation. Finally, we consider combined treatment strategies to improve the particle therapy of radioresistant cancers.
Document type :
Journal articles
Complete list of metadata
https://hal-normandie-univ.archives-ouvertes.fr/hal-02429129
Contributor : Carole Brunaud <>
Submitted on : Wednesday, July 8, 2020 - 2:50:28 PM
Last modification on : Wednesday, August 25, 2021 - 2:38:02 PM
Long-term archiving on: : Monday, November 30, 2020 - 3:17:03 PM
Contributor : Carole Brunaud <>
Submitted on : Wednesday, July 8, 2020 - 2:50:28 PM
Last modification on : Wednesday, August 25, 2021 - 2:38:02 PM
Long-term archiving on: : Monday, November 30, 2020 - 3:17:03 PM
File
ijms-21-00133-v2.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : hal-02429129, version 1
- DOI : 10.3390/ijms21010133
Collections
ABTE | LPC-CAEN | ENSICAEN | UNICAEN | CNRS | CEA | IRAMIS-CIMAP | ISTCT | COMUE-NORMANDIE | ISTCT-CERVOXY | UNIROUEN | IN2P3 | LPCC-AMI | CIMAP | ARIA-CIMAP | IRAMIS | GS-ENGINEERING
Citation
Juliette Thariat, Samuel Valable, Carine Laurent, Siamak Haghdoost, Elodie Pérès, et al.. Hadrontherapy Interactions in Molecular and Cellular Biology. International Journal of Molecular Sciences, MDPI, 2020, 21 (1), pp.133. ⟨10.3390/ijms21010133⟩. ⟨hal-02429129⟩
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