HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Chromogranin A in the early steps of the neurosecretory pathway

Abstract : Chromogranin A (CgA) is a soluble glycoprotein stored with hormones and neuropeptides in secretory granules (SG) of most (neuro)endocrine cells and neurons. Since its discovery in 1967, many studies have reported its structural characteristics, biological roles, and mechanisms of action. Indeed, CgA is both a precursor of various biologically active peptides and a granulogenic protein regulating the storage and secretion of hormones and neuropeptides. This review emphasizes the findings and theoretical concepts around the CgAlinked molecular machinery controlling hormone/neuropeptide aggregation and the interaction of CgA-hormone/neuropeptide aggregates with the trans- Golgi membrane to allow hormone/neuropeptide targeting and SG biogenesis. We will also discuss the intriguing alteration of CgA expression and secretion in various neurological disorders, which could provide insights to elucidate the molecular mechanisms underlying these pathophysiological conditions.
Complete list of metadata

https://hal-normandie-univ.archives-ouvertes.fr/hal-02427300
Contributor : Maïté Montero-Hadjadje Connect in order to contact the contributor
Submitted on : Friday, January 3, 2020 - 2:29:24 PM
Last modification on : Friday, March 11, 2022 - 2:09:47 PM

Links full text

Identifiers

Collections

Citation

Fanny Laguerre, Youssef Anouar, Maite Montero-Hadjadje. Chromogranin A in the early steps of the neurosecretory pathway. IUBMB Life, Wiley, 2019, ⟨10.1002/iub.2218⟩. ⟨hal-02427300⟩

Share

Metrics

Record views

27