Cell cycle, CDKs and cancer: a changing paradigm, Nat Rev Cancer, vol.9, pp.153-166, 2009. ,
Targeting CDK4 and CDK6: From discovery to therapy, Cancer Discov, vol.6, pp.353-367, 2016. ,
Cyclins and cell cycle control in cancer and disease, Genes Cancer, vol.3, pp.649-657, 2013. ,
The landscape of somatic copy-number alteration across human cancers, Nature, vol.463, pp.899-905, 2010. ,
Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases, Nat Rev Mol Cell Biol, vol.17, pp.280-292, 2016. ,
CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma, Oncotarget, vol.7, pp.73558-73572, 2016. ,
Alternative cyclin D1 splice forms differentially regulate the DNA damage response, Cancer Res, vol.70, pp.8802-8811, 2010. ,
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers, Nature, vol.474, pp.230-234, 2011. ,
The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2, Oncogene, vol.29, pp.5103-5112, 2010. ,
ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice, J Clin Invest, vol.122, pp.833-843, 2012. ,
Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium, Cancer Res, vol.72, pp.6477-6489, 2012. ,
Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence, J Cell Sci, p.131, 2018. ,
Cyclin D1 restrains oncogene-induced autophagy by regulating the AMPK-LKB1 signaling axis, Cancer Res, vol.77, pp.3391-3405, 2017. ,
Cyclin D1 determines mitochondrial function in vivo, Mol Cell Biol, vol.26, pp.5449-5469, 2006. ,
Cyclin D1 inhibits mitochondrial activity in B cells, Cancer Res, vol.71, pp.1690-1699, 2011. ,
Cyclin D1 governs adhesion and motility of macrophages, Mol Biol Cell, vol.14, pp.20-25, 2003. ,
Cyclin D1 induction of cellular migration requires p27(KIP1), Cancer Res, vol.66, pp.9986-9994, 2006. ,
Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration, J Biol Chem, pp.7007-7015, 2008. ,
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression, Nature, vol.510, pp.547-551, 2014. ,
Cyclin D1 represses peroxisome proliferatoractivated receptor alpha and inhibits fatty acid oxidation, Oncotarget, vol.7, pp.47674-47686, 2016. ,
Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma, Nat Commun, vol.10, p.1296, 2019. ,
CDK4/6 inhibition triggers anti-tumour immunity, Nature, vol.548, pp.471-475, 2017. ,
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance, Nature, vol.553, pp.91-95, 2018. ,
Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells, Cancer Res, vol.70, pp.2105-2114, 2010. ,
Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors, Cell Cycle, vol.14, pp.1786-1798, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02187383
Cyclin D1, cancer progression, and opportunities in cancer treatment, J. Mol. Med, vol.94, pp.1313-1326, 2016. ,
Cell cycle proteins as promising targets in cancer therapy, Nat Rev Cancer, vol.17, pp.93-115, 2017. ,
Glycogen synthase kinase-3 beta regulates cyclin D1 proteolysis and subcellular localization, Genes Dev, vol.12, pp.3499-3511, 1998. ,
ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover, Cell Signal, vol.20, pp.1986-1994, 2008. ,
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation, PLoS One, vol.1, p.128, 2006. ,
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage, Nature, vol.459, pp.722-725, 2009. ,
Phosphorylation-Dependent Ubiquitinationof Cyclin D1 by the SCFFBX4-aB Crystallin Complex, Mol Cell, vol.24, pp.355-366, 2006. ,
Mutations in Fbx4 inhibit dimerization of the SCFFbx4 ligase and contribute to cyclin D1 overexpression in human cancer, Cancer Cell, vol.14, pp.68-78, 2008. ,
The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation, Mol Cell Biol, vol.31, pp.4513-4523, 2011. ,
Small molecule inhibition of the ubiquitin-specific protease USP2 accelerates cyclin D1 degradation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma models, J Biol Chem, vol.291, pp.24628-24640, 2016. ,
Suppression of cancer cell growth by promoting cyclin D1 degradation, Mol Cell, vol.36, pp.469-476, 2009. ,
Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes, J Clin Invest, vol.123, pp.493-508, 2012. ,
Prognostic and clinicopathological significance of cyclin D1 expression in oral squamous cell carcinoma: A systematic review and meta-analysis, Oral Oncol, vol.83, pp.96-106, 2018. ,
Molecular pathology and genetics of pancreatic endocrine tumours, J Mol Endocrinol, vol.49, pp.37-50, 2012. ,
Genetic alterations in main candidate genes during melanoma progression, Oncotarget, vol.9, pp.8531-8541, 2018. ,
Cyclin D1 is significantly associated with stage of tumor and predicts poor survival in endometrial carcinoma patients, Ann Diagn Pathol, vol.30, pp.47-51, 2017. ,
The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer, Genes Chromosomes Cancer, vol.56, pp.769-787, 2017. ,
Comprehensive genomic profiles of small cell lung cancer, Nature, vol.524, pp.47-53, 2015. ,
The molecular pathogenesis of mantle cell lymphoma, Leuk Lymphoma, vol.58, pp.1530-1537, 2017. ,
Cyclin D as a therapeutic target in cancer, Nat Rev Cancer, vol.11, pp.558-572, 2011. ,
Cyclin D1 gene (CCND1) mutations in endometrial cancer, Oncogene, vol.22, pp.6115-6118, 2003. ,
Identification of mutations that disrupt phosphorylationdependent nuclear export of cyclin D1, Oncogene, vol.25, pp.6291-6303, 2006. ,
Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival, Blood, vol.109, pp.4599-4606, 2007. ,
UTR mediated regulation of the cyclin D1 proto-oncogene, Cell Cycle, vol.8, pp.3592-3600, 2014. ,
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells, Proc Natl Acad Sci USA, vol.115, pp.9298-9307, 2018. ,
The cyclin D1b splice variant: an old oncogene learns new tricks, Cell Div, vol.1, p.15, 2006. ,
Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation, J Biol Chem, vol.278, pp.30339-30347, 2003. ,
Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer, Clin Cancer Res, vol.15, pp.5338-5349, 2009. ,
Alternative cyclin D1 forms a and b have different biological functions in the cell cycle of B lymphocytes, Exp Cell Res, vol.313, pp.2719-2729, 2007. ,
An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene, Cancer Res, vol.63, pp.7056-7051, 2003. ,
Consequence of the tumor-associated conversion to cyclin D1b, EMBO Mol Med, vol.7, pp.628-647, 2015. ,
Association between CCND1 G/A870 polymorphism, allelespecific amplification, cyclin D1 expression, and survival in esophageal and lung carcinoma, Clin Cancer Res, vol.14, pp.7804-7812, 2008. ,
Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome, Oncogene, vol.28, pp.1812-1820, 2009. ,
Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma, Oncogene, vol.25, pp.998-1007, 2005. ,
Impact of differential cyclin D1 expression and localisation in prostate cancer, Br J Cancer, vol.96, pp.970-979, 2007. ,
High-level cytoplasmic cyclin D1 expression in lymph node metastases from prostate cancer independently predicts early biochemical failure and death in surgically treated patients, Histopathology, vol.58, pp.781-789, 2011. ,
Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer, Oncotarget, vol.7, pp.26979-26991, 2016. ,
Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells, Sci Rep, vol.7, p.13946, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01725070
Cytoplasmic cyclin D1 regulates glioblastoma dissemination, J. Pathol, vol.248, pp.501-513, 2019. ,
Living with or without cyclins and cyclin-dependent kinases, Genes Dev, vol.18, pp.2699-2711, 2004. ,
Cyclins: roles in mitogenic signaling and oncogenic transformation, Growth Factors, vol.24, pp.13-19, 2006. ,
Cyclin-dependent kinases regulate the antiproliferative function of Smads, Nature, vol.430, pp.226-231, 2004. ,
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells, Cancer Cell, vol.20, pp.620-634, 2011. ,
Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen, Nature, vol.463, pp.374-378, 2010. ,
Transcriptional regulation by a DNA-associated form of cyclin D1, Mol Biol Cell, vol.16, pp.1850-1858, 2005. ,
New roles of cyclin D1, Am J Pathol, vol.183, pp.3-9, 2013. ,
P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor, Proc Natl Acad Sci USA, vol.96, pp.5382-5387, 1999. ,
Cyclin D1b represses breast cancer cell growth by antagonizing the action of cyclin D1a on estrogen receptor ?-mediated transcription, Int J Oncol, vol.36, pp.39-48, 2009. ,
A central domain of cyclin D1 mediates nuclear receptor corepressor activity, Oncogene, vol.24, pp.431-444, 2004. ,
Cyclin D1 binding to the androgen receptor (AR) NH2-terminal domain inhibits activation function 2 association and reveals dual roles for AR corepression, Mol Endocrinol, vol.19, pp.607-620, 2005. ,
Cyclin D1 inhibits peroxisome proliferator-activated receptor ?-mediated adipogenesis through histone deacetylase recruitment, J Biol Chem, vol.280, pp.16934-16941, 2005. ,
Aberrant expression of cyclin D1 in cancer, Sign Transduct Insights, vol.4, pp.1-13, 2015. ,
Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer, Am J Pathol, vol.183, pp.1339-1350, 2013. ,
Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms, J Clin Invest, vol.128, pp.4132-4147, 2018. ,
Cyclin D1 integrates G9a-mediated histone methylation, Oncogene, vol.38, pp.4232-4249, 2019. ,
A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation, Nucleic Acids Res, vol.47, pp.9557-9572, 2019. ,
The trinity at the heart of the DNA damage response, Mol Cell, vol.66, pp.801-817, 2017. ,
Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts, Genes Dev, vol.8, pp.1627-1639, 1994. ,
Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication, Genes Dev, vol.21, pp.2908-2922, 2007. ,
Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells, Cell Cycle, vol.12, pp.773-782, 2013. ,
Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability, Mol Cell Biol, vol.28, pp.7245-7258, 2008. ,
ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis, Oncogene, vol.33, pp.129-133, 2013. ,
Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis, Oncotarget, vol.6, pp.8525-8538, 2015. ,
Proteomic identification of a direct role for cyclin D1 in DNA damage repair, Cancer Res, vol.72, pp.4289-4293, 2012. ,
Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage, Oncotarget, vol.7, pp.5383-5400, 2016. ,
Cyclin D1 antagonizes BRCA1 repression of estrogen receptor ? activity, Cancer Res, vol.65, pp.6557-6567, 2005. ,
Cyclin D1 promotes BRCA2-Rad51 interaction by restricting cyclin A/B-dependent BRCA2 phosphorylation, Oncogene, vol.35, pp.2815-2823, 2016. ,
Cyclin D1 integrates estrogen-mediated DNA damage signaling, Cancer Res, vol.74, pp.3959-3970, 2014. ,
Hallmarks of cancer: the next generation, Cell, vol.144, pp.646-674, 2011. ,
Cell adhesion: integrating cytoskeletal dynamics and cellular tension, Nat Rev Mol Cell Biol, vol.11, pp.633-643, 2010. ,
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling, Mol Cell Biol, vol.26, pp.4240-4256, 2006. ,
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin, Nature Commun, vol.7, p.11581, 2016. ,
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation, J Cell Biol, vol.182, pp.509-517, 2008. ,
Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer, Nature Commun, vol.4, p.2812, 2013. ,
Cyclin D1 represses gluconeogenesis via inhibition of the transcriptional coactivator PGC1, Diabetes, vol.63, pp.3266-3278, 2014. ,
Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4?, Cell Cycle, vol.11, pp.2681-2690, 2012. ,
Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function, Proc Natl Acad Sci USA, vol.103, pp.11567-11572, 2006. ,
The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival, Nature, vol.546, pp.426-430, 2017. ,
Mammary hyperplasia and carcinoma in MMTVcyclin D1 transgenic mice, Nature, vol.369, pp.669-671, 1994. ,
Specific protection against breast cancers by cyclin D1 ablation, Nature, vol.411, pp.1017-1021, 2001. ,
The requirement for cyclin D function in tumor maintenance, Cancer Cell, vol.22, pp.438-451, 2012. ,
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis, Cancer Cell, vol.9, pp.13-22, 2006. ,
Requirement for CDK4 kinase function in breast cancer, Cancer Cell, vol.9, pp.23-32, 2006. ,
Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice, EMBO J, vol.13, pp.3487-3495, 1994. ,
Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene, EMBO J, vol.13, pp.2124-2130, 1994. ,
Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis, Oncogene, vol.27, pp.1231-1242, 2007. ,
Female-specific rectal carcinogenesis in cyclin D1b transgenic mice, Carcinogenesis, vol.35, pp.227-236, 2014. ,
Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene, Cancer Res, vol.70, pp.3975-3984, 2010. ,
Alternative splicing of the cyclin D1 protooncogene is regulated by the RNA-binding protein Sam68, Cancer Res, vol.70, pp.229-239, 2010. ,
The human SWI/SNF subunit Brm is a regulator of alternative splicing, Nat Struct Mol Biol, vol.13, pp.22-29, 2005. ,
The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis, Cell Cycle, vol.13, pp.2889-2900, 2014. ,
Treating cancer with selective CDK4/6 inhibitors, Nat Rev Clin Oncol, vol.13, pp.417-430, 2016. ,
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase, Cancer Cell, vol.18, pp.329-340, 2010. ,
Regulation of the master regulator FOXM1 in cancer, Cell Commun Signal, vol.16, p.57, 2018. ,
Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility, Oncogene, vol.30, pp.1936-1946, 2011. ,
PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b, Cell Cycle, vol.10, pp.73-81, 2011. ,
Cyclin D1 sensitizes myeloma cells to endoplasmic reticulum stress-mediated apoptosis by activating the unfolded protein response pathway, BMC Cancer, vol.15, pp.262-273, 2015. ,
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update, Nucleic Acids Res, vol.44, pp.90-97, 2016. ,
WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research, Nucleic Acids Res, vol.46, pp.661-667, 2017. ,