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Journal articles
Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one, a Promising Inhibitor of DYRK1A
Abstract : Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) hyperactivity has been linked to the development of a number of human malignancies. DYRK1A is the most studied family member, and the discovery of novel specific inhibitors is attracting considerable interest. The 8-cyclopropyl-2(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one (also called FC162) was found to be a promising inhibitor of DYRK1A and was characterized in biological experiments, by western transfer and flow cytometry on SH-SY5Y and pre-B cells. Here, the results obtained with FC162 are compared to well-characterized known DYRK1A inhibitors (e.g., Leucettine L41 and EHT1610).
https://hal-normandie-univ.archives-ouvertes.fr/hal-02417254
Contributor : Madeleine Roux-Merlin <>
Submitted on : Thursday, May 27, 2021 - 8:44:12 AM
Last modification on : Thursday, May 27, 2021 - 1:54:16 PM
Long-term archiving on: : Saturday, August 28, 2021 - 6:10:02 PM
Contributor : Madeleine Roux-Merlin <>
Submitted on : Thursday, May 27, 2021 - 8:44:12 AM
Last modification on : Thursday, May 27, 2021 - 1:54:16 PM
Long-term archiving on: : Saturday, August 28, 2021 - 6:10:02 PM
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pharmaceuticals-12-00185.pdf
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