The Pressure-Temperature Phase Diagram of Metacetamol and Its Comparison to the Phase Diagram of Paracetamol

Maria Barrio (1) , Judit Huguet (1) , Ivo Rietveld (2) , Benoit Robert (3) , René Céolin (4) , Josep-Lluis Tamarit (1)

1 UPC - Universitat Politècnica de Catalunya [Barcelona]
2 SMS - Sciences et Méthodes Séparatives
3 Sanofi [Vitry-sur-Seine]
4 LETIAM - Laboratoire d'Etudes des Techniques et Instruments d'Analyse Moleculaire

Keywords: Solid state; Phase behaviour; Calorimetry; crystal polymorphism; physical characterisation; physical stability; Topological phase diagram; Thermodynamics; Thermal expansion

Domains: Chemical Sciences; Analytical chemistry; Chemical Sciences; Cristallography; Chemical Sciences; Material chemistry; Chemical Sciences; Theoretical and/or physical chemistry; Life Sciences [q-bio]; Pharmaceutical sciences; Medication

Maria Barrio, Judit Huguet, Ivo Rietveld, Benoit Robert, René Céolin, et al.. The Pressure-Temperature Phase Diagram of Metacetamol and Its Comparison to the Phase Diagram of Paracetamol. Journal of Pharmaceutical Sciences, 2017, 106 (6), pp.1538-1544. ⟨10.1016/j.xphs.2017.02.003⟩. ⟨hal-02414749⟩