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Design and synthesis of novel potent anticoagulant and anti-tyrosinase pyranopyrimidines and pyranotriazolopyrimidines Insights from molecular docking and SAR analysis

Abstract : Pyrimidine-fused compounds are of great interest for the discovery of potent bioactive agents. This study describes the synthesis of novel pyranopyrimidines 3a-f and pyranotriazolopyrimidines 4a-d derivatives via the cyclocondensation reaction of α-functionalized iminoether 2, which was obtained from 2-amino-3-cyanopyrane 1, with a series of primary aromatic amines and hydrazides, respectively. Structures of all synthesized compounds were established on the basis of spectroscopic methods including 1H NMR, 13C NMR and ES-HRMS. They were finally tested for their anticoagulant and anti-tyrosinase activities. Significant results have been obtained and the structure-activity relationship (SAR) was discussed with the help of molecular docking analysis. © 2018
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02413307
Contributor : Vincent Loisel <>
Submitted on : Monday, December 16, 2019 - 10:45:02 AM
Last modification on : Tuesday, October 20, 2020 - 6:48:06 PM

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Meriem Debbabi, Vijaykumar D. Nimbarte, Samia Chekir, Sarra Chortani, Anis Romdhane, et al.. Design and synthesis of novel potent anticoagulant and anti-tyrosinase pyranopyrimidines and pyranotriazolopyrimidines Insights from molecular docking and SAR analysis. Bioorganic Chemistry, Elsevier, 2019, 82, pp.129-138. ⟨10.1016/j.bioorg.2018.10.004⟩. ⟨hal-02413307⟩

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