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Triflic Acid Catalyzed Intermolecular α-Amination of Pterolactams to Give 5-Arylaminopyrrolidinones via N-Acyliminium Species

Abstract : A mild and efficient α-aza-amidoalkylation for the synthesis of 5-arylaminopyrrolidinones is presented. The key step of this reaction is the intermolecular interception of an N-acyliminium species, generated under the acidic conditions, with nitrogen nucleophiles such as N-silylamines. © Georg Thieme Verlag Stuttgart New York.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02413305
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Submitted on : Monday, December 16, 2019 - 10:44:51 AM
Last modification on : Thursday, July 2, 2020 - 3:29:03 AM

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Gina-Mirabela Dumitriu, Elena Bîcu, Ulku Eryuruk, Dalila Belei, Benoît Rigo, et al.. Triflic Acid Catalyzed Intermolecular α-Amination of Pterolactams to Give 5-Arylaminopyrrolidinones via N-Acyliminium Species. SYNLETT, Georg Thieme Verlag, 2016, 27 (6), pp.934-940. ⟨10.1055/s-0035-1561333⟩. ⟨hal-02413305⟩

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