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An innovative and efficient method to synthesize meloxicam in one-step procedure with respect to the green chemistry

Abstract : An improved procedure for the synthesis of meloxicam drug (methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazol-2-amine-3-carboxylate 1,1-dioxide) was described in one-step using mainly impregnated montmorillonite K10 (MK10) with ZnCl 2 as a heterogeneous catalyst. This innovative method was compared to the last described procedure employed in the manufacture of this anti-inflammatory drug by means of some metrics used in a first step of the evaluation process of the environmental impact of a chemical transformation. Apart from the yield, which was 90%, atom economy, waste, environmental factor, reaction mass efficiency and stoichiometric factor were calculated as 91.6%, 8.4%, 0, 8.1% and 1%, respectively. Interpretation of these metrics was given and highlighted the fact that the strategy used in the current study may be considered as an environmental-friendly and sustainable method that fits well in the green chemistry concepts. © 2018, Iranian Chemical Society.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02413304
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Submitted on : Monday, December 16, 2019 - 10:44:47 AM
Last modification on : Wednesday, August 5, 2020 - 3:44:20 AM

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Pierrick Dufrénoy, Alina Ghinet, Marie Hechelski, Adam Daïch, Christophe Waterlot. An innovative and efficient method to synthesize meloxicam in one-step procedure with respect to the green chemistry. Journal- Iranian Chemical Society, Iranian Chemical Society, 2019, 16 (3), pp.501-509. ⟨10.1007/s13738-018-1525-6⟩. ⟨hal-02413304⟩

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