Sequential friedel-crafts-type α-amidoalkylation/intramolecular hydroarylation Distinct advantage of combined Tf2NH/cationic LAu(I) as a consecutive or binary bicatalytic system

Liliana Boiaryna (1) , Mohamed Salah Azizi (1) , Abderrahman El Bouakher (1) , Baptiste Picard (1) , Catherine Taillier (1) , Mohamed Othman (1) , Malika Trabelsi-Ayadi (2) , Vincent Dalla (1)

1 URCOM - Unité de Recherche en Chimie Organique et Macromoléculaire
2 Université de Carthage - University of Carthage

The combined use of Tf2NH and L(Au)+X- as a dual or binary catalytic system clearly improves the efficiency and enlarges the scope of the tandem intermolecular Friedel-Crafts α-amidoalkylation/intramolecular hydroarylation sequence, compared to an "all gold" multicatalysis approach. © 2015 American Chemical Society.

Domains: Chemical Sciences

Liliana Boiaryna, Mohamed Salah Azizi, Abderrahman El Bouakher, Baptiste Picard, Catherine Taillier, et al.. Sequential friedel-crafts-type α-amidoalkylation/intramolecular hydroarylation Distinct advantage of combined Tf2NH/cationic LAu(I) as a consecutive or binary bicatalytic system. Organic Letters, 2015, 17 (9), pp.2130-2133. ⟨10.1021/acs.orglett.5b00718⟩. ⟨hal-02413298⟩