, 300 MHz, CDCl 3 ): d (ppm) 2.91-2.98 (m, 1H, CH), 3.01-3.21 (m, 1H, CH), 3.51-3.60 (m, 1H, CH), 4.64-4.71 (m, 1H, CH), 5.81 (s, 1H, CHN), 7.17-7.30 (m, 3H, CHar), 7.60 (t, 1H, J = 7.34 Hz, CHar), 7.82 (t, 1H, J = 7.63 Hz, CHar), 7.97 (d, 1H, J = 8.1 Hz, CHar), vol.8
8 (CHar), 129.6 (CHar), 129.7 (CHar), 131.4 (CHar), vol.37 ,
, Mp 213-215°C (ethyl acetate/cyclohexane, decomposition)
, IR (cm À1 ) m: 3020 (CH), 2987 (CH), 1694 (C?O), p.1722
, CDCl 3 ): d (ppm) 2.90-2.95 (m, 1H, CH), 3.29-3.32 (m, 1H, CH), 3.53-3.60 (m, 1H, CH), 4.32-4.39 (m, 1H, CH), 7.17-7.33 (m, 3H, CHar), vol.7
4 (q, 1 J = 284.5 Hz, C q CF 3 ), 122.2 (C q ), 126.1 (CHar), 127.4 (C q ), 127.6 (CHar), vol.8, p.134 ,
, IR (cm À1 ) m: 3010 (CH), 2987 (CH), p.1708
CDCl 3 ): d (ppm) 12.2 (CH 3 ), 1H, CH), 4.60-4.65 (m, 1H, CH), 5.72 (s, 1H, CHN), 7.15-7.35 (m, 4H, CHar), 7.63 (t, 1H, J = 7.82 Hz, CHar), 7.85 (t, 1H, J = 7.82 Hz, CHar), vol.3 ,
, ] quinolin-8(6H)-one (6ca) This product was obtained as a white solid in 72% yield starting from hydroxy lactam 12ca according to the Method A, pp.169-171
, IR (cm À1 ) m: 3014 (CH), 2986 (CH), p.1702
, 300 MHz, CDCl 3 ): d (ppm) 2.84-2.92 (m, 1H, CH), 3.03-3.20 (m, 1H, CH), 3.46-3.53 (m, 1H, CH), 4.53-4.64 (m, 1H, CH), 5.80 (s, 1H, CHN), 7.16 (t, 1H, J = 6.26 Hz, CHar), 7.29-7.55 (m, 8H, CHar)
0 (CHar), 127.4 (2 Â CHar), 127.6 (CHar), 128.0 (CHar), 128.2 (C q ), Â CHar), 130.0 (CHar), 131.0 (CHar), 132.7 (C q ), vol.37 ,
, IR (cm À1 ) m: 3021 (CH), 2982 (CH), 1706 (C?O), p.1730
, CDCl 3 ): d (ppm) 2.86-2.92 (m, 1H, CH), 3.04-3.16 (m, 1H, CH), 3.62-3.72 (m, 1H, CH), 4.47-4.53 (m, 1H, CH), 7.16 (d, 1H, J = 7.54 Hz, CHar), 7.29-7.39 (m, 4H, CHar), 7.50-7.74 (m, 4H, CHar)
3 (CHar), 129.8 (CHar), vol.128 ,
, , vol.164
Calcd for C 27 H 17 F 3 N 2 O 3 (474.43): C, 68, p.35 ,
, N, 5.90. Found. C, 68.28
, IR (cm À1 ) m: 3012 (CH), 2989 (CH), p.1698
17 (d, 1H, J = 8.72 Hz, CHar), 8.37 (d, 1H, J = 7.82 Hz, CHar); 13 C NMR (75 MHz, 1H, CH), 5.72 (s, 1H, CHN), 7.11-7.16 (m, 3H, CHar), 7.28-7.31 (m, 3H, CHar), 7.56-7.59 (m, 4H, CHar), vol.8 ,
,
, IR (cm À1 ) m: 3012 (CH), 2985 (CH), p.1704
, CDCl 3 ): d (ppm) 2.75-2.85 (m, 1H, CH), 2.92-2.98 (m, 1H, CH)
93 (s, 1H, CHar), 8.15 (d, 1H, J =, vol.7, p.29 ,
53 (s, 1H, CHar); 13 C NMR (75 MHz, Â CHar), vol.8 ,
, 4 (CHar), 129.8 (CHar), 131.6 (CHar), vol.127
, 2-Methoxy-9-methyl-5,14b-dihydrobenzo
, IR (cm À1, p.1700
, 14 (s, 3H, CH 3 ), 3.43-3.50 (m, 1H, CH), 3.87 (s, 3H, CDCl 3 ): d (ppm) 2.82-2.88 (m, 1H, CH), 3.00-3.10 (m, 1H, CH), vol.3, p.75
 CHar), 120.6 (C q ), 123.6 (CHar), 125.5 (CHar), CDCl 3 ): d (ppm) 12.7 (CH 3 ), vol.27 ,
, , pp.189-191
, IR (cm À1 ) m: 3012 (CH), 2993 (CH), p.1705
, 1H, CH), 3.91 (s, 3H, OCH 3 ), 4.53-4.64 (m, 1H, CH), 5.78 (s, 1H, CHN), 6.79 (d, 1H, J = 7.83 Hz, CHar), 7.07 (d, 1H, J = 7.83 Hz, CHar), 7.41-7.56 (m, 7H, CHar), 7.82-7.86 (m, 2H, CHar), 8.36 (d, 1H, J = 7.82 Hz, CHar); 13 C NMR (75 MHz, CDCl 3 ): d (ppm) 28.0 (CH 2 ), vol.37
, 11-Chloro-2-methoxy-9-phenyl-5,14b-dihyd-robenzo [7,8]indolizino[1,2-b]quinolin-8(6H)-one (6db) This product was obtained as a white solid in 73% yield starting from hydroxy lactam 12db according to the Method B, pp.183-185
, CDCl 3 ): d (ppm) 2.77-2.80 (m, IR (cm À1, vol.1, p.1700
23 (d, 1H, J = 8.6 Hz, CHar); 13 C NMR (75 MHz, 2H, CHar), 7.53-7.62 (m, 3H, CHar), 7.76 (m, 2H, CHar), 8.09 (d, 1H, J = 2.36 Hz, CHar), vol.8, pp.182-184 ,
, CDCl 3 ): d (ppm) 2.77-2.85 (m, IR (cm À1 ) m: 3014 (CH), 2984 (CH), vol.1, p.1705
46 (s, 1H, CHar); 13 C NMR (75 MHz, C q ), 129.4 (CHar), 129.8 (CHar), 131.6 (CHar), 132.7 (CHar), vol.8, pp.180-182 ,
, IR (cm À1 ) m: 3013 (CH), 2989 (CH), p.1681
84 (s, 3H, OCH 3 ), 4.00 (s, 3H, OCH 3 ), 4.69-4.77 (m, 1H, CH), 5.65 (s, 1H, CHN), 6.62 (s, 1H, CHar), Hz, CHar), 7.78 (t, 1H, J = 7.34 Hz, CHar), vol.3, p.63 ,
, 3-Dimethoxy-9-phenyl-5,14b-dihydro-benzo[7,8] indolizino[1,2-b]quinolin-8(6H)-one (6cc) This product was obtained as a white-yellow solid in 67% yield starting from hydroxy lactam 12 cc according to the Method B, vol.2, pp.215-217
116.6 (C q ), 112.2 (CHar), 116.8 (CHar), 120.6 (C q ), 126.5 (C q ), 126.6 (CHar), OCH 3 ), 4.59-4.68 (m, 1H, CH), 5.78 (s, 1H, CHN), 6.64 (s, 1H, CHar), 7.43-7.53 (m, 6H, CHar), 7.80-7.81 (m, 2H, CHar), vol.3, p.1692 ,
, CDCl 3 ): d (ppm) 2.66-2.70 (m, 1H, CH), 2.94-2.99 (m, 1H, CH), 3.31-3.35 (m, 1H, CH), 3.78 (s, 3H, OCH 3 ), 3.96 (s, 3H, IR (cm À1 ) m: 3018 (CH), 2996 (CH), p.75
CDCl 3 ): d (ppm) 28.3 (CH 2 ), vol.37, p.9 ,
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