New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities

Aymen Ben Nejma (1) , Asma Nguir (1) , Hichem Ben Jannet (1) , M’hamed Ali Hamza (1) , Adam Daïch (2, 3) , Mohamed Othman (2) , Ata Martin Lawson (2)

1 UM - Université de Monastir - University of Monastir
2 URCOM - Unité de Recherche en Chimie Organique et Macromoléculaire
3 INC3M - Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire

The phytochemical investigation of a Tunisian plant Atriplex portulacoides (Chenopodiaceae) led to the isolation of two new compounds designated as portulasoid (2) and septanoecdysone (3) along with the known 20-hydroxyecdysone (20HE) (1). Their chemical structures were elucidated on the basis of extensive spectroscopic methods including ES-HRMS, 1D and 2D-NMR. The isolated compounds were finally tested for their antioxidant activity by using DPPH, ABTS+, Fe3+ and catalase assays and also for their antibacterial and anticholinesterase activities. © 2015 Elsevier Ltd.

Keywords: NMR; Chenopodiaceae; Septanoecdysone; Portulasoid; 20-Hydroxyecdysone; Atriplex portulacoides; Biological activities

Domains: Chemical Sciences

Aymen Ben Nejma, Asma Nguir, Hichem Ben Jannet, M’hamed Ali Hamza, Adam Daïch, et al.. New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities. Bioorganic and Medicinal Chemistry Letters, 2015, 25 (8), pp.1665-1670. ⟨10.1016/j.bmcl.2015.03.028⟩. ⟨hal-02413288⟩