Highly Stereoselective Domino Oxa-Michael/Aza-Michael/Cyclization Synthesis of Bicyclic Lactams and Spirooxindole Skeleton

R. Le Goff (1) , M. Sanselme (2) , Ata Martin Lawson (1) , Adam Daïch (1, 3) , Sébastien Comesse (1)

1 URCOM - Unité de Recherche en Chimie Organique et Macromoléculaire
2 SMS - Sciences et Méthodes Séparatives
3 INC3M - Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire

Keywords: Domino reactions; Meyers' bicyclic lactams; Bromoacetamides; Michael acceptors; Diastereoselectivity

Domains: Chemical Sciences

R. Le Goff, M. Sanselme, Ata Martin Lawson, Adam Daïch, Sébastien Comesse. Highly Stereoselective Domino Oxa-Michael/Aza-Michael/Cyclization Synthesis of Bicyclic Lactams and Spirooxindole Skeleton. European Journal of Organic Chemistry, 2015, 2015 (33), pp.7244-7248. ⟨10.1002/ejoc.201501072⟩. ⟨hal-02413286⟩