Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction

Hanen Saggadi; Denis Luart; Nicolas Thiebault; Isabelle Polaert; Lionel Estel; Christophe Len

doi:10.1016/j.catcom.2013.07.029

Journal articles

Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction

Hanen Saggadi ^{1, 2} Denis Luart ¹ Nicolas Thiebault ¹ Isabelle Polaert ² Lionel Estel ² Christophe Len ¹

1 TIMR - Transformation Intégrée de la Matière Renouvelable

2 LSPC - Laboratoire de Sécurité des Procédés Chimiques

Abstract : An efficient and modified Skraup reaction and Bamberger rearrangement in neat water were developed using nitrobenzene and an inexpensive, abundant and environmentally-friendly glycerol under microwave irradiation conditions was furnish regioselectively to the 6-hydroxyquinoline. The target compound was obtained in 77% yield via efficient domino reaction with a “one pot eleven steps”.

Keywords : Glycerol Skraup Bamberger Aqueous catalysis 6-hydroxyquinoline Microwaves Domino reaction

Document type :

Journal articles

Domain :

Engineering Sciences [physics] / Chemical and Process Engineering

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https://hal-normandie-univ.archives-ouvertes.fr/hal-02409886
Contributor : Isabelle Polaert Connect in order to contact the contributor
Submitted on : Friday, December 13, 2019 - 3:51:22 PM
Last modification on : Tuesday, November 16, 2021 - 4:43:43 AM

Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction

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Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction

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