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Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction

Abstract : An efficient and modified Skraup reaction and Bamberger rearrangement in neat water were developed using nitrobenzene and an inexpensive, abundant and environmentally-friendly glycerol under microwave irradiation conditions was furnish regioselectively to the 6-hydroxyquinoline. The target compound was obtained in 77% yield via efficient domino reaction with a “one pot eleven steps”.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02409886
Contributor : Isabelle Polaert <>
Submitted on : Friday, December 13, 2019 - 3:51:22 PM
Last modification on : Thursday, February 6, 2020 - 9:18:02 AM

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Hanen Saggadi, Denis Luart, Nicolas Thiebault, Isabelle Polaert, Lionel Estel, et al.. Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction. Catalysis Communications, Elsevier, 2014, 44, pp.15-18. ⟨10.1016/j.catcom.2013.07.029⟩. ⟨hal-02409886⟩

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