Quinoline and phenanthroline preparation starting from glycerol via improved microwave-assisted modified Skraup reaction

Hanen Saggadi (1, 2) , Denis Luart (1) , Nicolas Thiebault (1) , Isabelle Polaert (2) , Lionel Estel (2) , C. Len (1)

1 TIMR - Transformation Intégrée de la Matière Renouvelable
2 LSPC - Laboratoire de Sécurité des Procédés Chimiques

An efficient “green” modified Skraup reaction in neat water was developed using inexpensive, abundant and environmentally-friendly glycerol under microwave irradiation conditions. Starting from aniline derivatives, various quinolines were obtained in 10–66% yields. The use of nitroaniline led to the corresponding phenanthrolines in 15–52% yields, respectively.

Domains: Engineering Sciences [physics]; Chemical and Process Engineering

Hanen Saggadi, Denis Luart, Nicolas Thiebault, Isabelle Polaert, Lionel Estel, et al.. Quinoline and phenanthroline preparation starting from glycerol via improved microwave-assisted modified Skraup reaction. RSC Advances, 2014, 4 (41), pp.21456-21464. ⟨10.1039/C4RA00758A⟩. ⟨hal-02409872⟩