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The maximum detrusor pressure as a predictive factor of success after sphincterotomy in detrusor-sphincter dyssynergia

Abstract : AIMS: To evaluate the impact of the pre-operative maximum detrusor pressure (MDP) on efficacy outcomes after incontinentation by sphincterotomy or urethral stent placement in male patients with neurogenic detrusor-sphincter dyssynergia (DSD). METHODS: A retrospective study was performed in 41 male patients treated between 2006 and 2013 in a tertiary reference center. All patients had a neurogenic DSD confirmed by baseline urodynamic studies, and were unable or secondary failed to practice CISC. Success was defined as a post-void residual volume <150 mL. Influence of MDP on treatment efficacy was evaluated through a Mann-Whitney U-Test. RESULTS: Median (range) age was 39 years (20-69). Spinal cord injury was the main underlying condition. Twenty-six patients had a sphincteric stent placement (Memocath®, Bard, Covington) and 15 had surgical sphincterotomy. Treatment was successful in 31 patients (76%). Patients with immediate successful outcomes had a significantly higher mean preoperative MDP (59.6 vs 29.7 cmH2 O; P = 0.002). Patients with MDP over the threshold of 40 cmH2 O had a 90% success rate. These differences were maintained at 6 months, MDP being higher in the success group than in the failure group (59.5 vs 39.8 cmH2 O, respectively, P = 0.008). The technique used (stent placement or incision) had no impact on immediate or 6-month success rates. CONCLUSIONS: Our results suggested that MDP is associated with treatment success rate after surgical management of DSD of neurogenic origin by sphincteric stent placement or surgical sphincterotomy. A threshold of 40 mH2 O is associated with higher success rates.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02406097
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Submitted on : Thursday, December 12, 2019 - 8:22:28 AM
Last modification on : Wednesday, August 19, 2020 - 11:17:58 AM

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Alexandre Hourié, François-Xavier Nouhaud, Maximilien Baron, John-David Rebibo, Christian Pfister, et al.. The maximum detrusor pressure as a predictive factor of success after sphincterotomy in detrusor-sphincter dyssynergia. Neurourology and Urodynamics, Wiley, 2018, 37 (8), pp.2758-2762. ⟨10.1002/nau.23759⟩. ⟨hal-02406097⟩

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