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Conference papers

Hepacivirus and the “new triade” : Further evidence for in utero transmission of equine hepacivirus to foals

Abstract : Equine hepacivirus (EqHV), also referred to as non-primate hepacivirus (NPHV), infects horses —and dogs in some instances— and is closely related to hepatitis C virus (HCV) that has infected up to 3 % of the world’s human population, causing an epidemic of liver cirrhosis and cancer. EqHV is also chronically infecting the liver of horses, but does not appear to cause serious liver damages. Recent work often associates two other viruses, Theiler Disease Associated Virus (TDAV) and Pegivirus (EqPV) to this research during hepatic syndrome. If the name of the hepatic triad has emerged in recent years, the recent discovery of a new virus, a potentially involved equine parvovirus, raises new questions. Among these, the mode of transmission of these viruses is an essential issue. Previous studies have been looking to identify route(s) of EqHV transmission to and between horses. In a retrospective study, we sought to evaluate the prevalence of vertical transmission taking place in utero with measuring by quantitative RT-PCR the amounts of EqHV genome in samples from 394 dead foals or fetuses, paired with the allantochorion whenever available. Detection of EqHV in three foals most likely resulted from a vertical transmission from the mares to the fetuses, consistent with the in-utero transmission hypothesis. In support of this observation, the presence of EqHV genome was found for the first time in two of the allantochorions. If the first transmission tracks emerge for EqHV, studies are needed for the "triad" or even the "tetrad".
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Submitted on : Tuesday, December 3, 2019 - 3:14:35 PM
Last modification on : Thursday, April 7, 2022 - 10:10:38 AM


  • HAL Id : hal-02391365, version 1


Stéphane Pronost, Christine Fortier, Christel Marcillaud Pitel, Jackie Tapprest, Marc Foursin, et al.. Hepacivirus and the “new triade” : Further evidence for in utero transmission of equine hepacivirus to foals. European Meeting of Equine Infectious Diseases, Nov 2019, Caen, France. ⟨hal-02391365⟩



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