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A novel synthesis of AZT

Abstract : A novel synthesis of AZT has been achieved from two commercial available products acetaldehyde and d-mannitol. The originality of the synthesis consists of using the powerful monovinylogation reagent, the 2-lithio-1-trimethylsiloxyethylene, and to introduce the thymine moiety and to build the furanose ring in the same and last step.
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Submitted on : Friday, November 29, 2019 - 9:30:44 AM
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Christine Gauthier, Yvan Ramondenc, Gérard Plé. A novel synthesis of AZT. Tetrahedron, Elsevier, 2001, 57 (35), pp.7513-7517. ⟨10.1016/S0040-4020(01)00695-0⟩. ⟨hal-02385788⟩



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