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An alternative route to the proline derivative (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid from protected glutamic acid

Abstract : The synthesis of (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid was achieved in two steps, with an overall yield of 53%. This synthesis used Cbz-Glu-OBzl as the starting material and led to the titled compound with a d.e.>96%.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02385515
Contributor : Laurent Bischoff <>
Submitted on : Thursday, November 28, 2019 - 6:53:29 PM
Last modification on : Thursday, July 30, 2020 - 3:12:14 AM

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Marie-Priscille Brun, Anne-Sophie Martin, Christiane Garbay, Laurent Bischoff. An alternative route to the proline derivative (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid from protected glutamic acid. Tetrahedron Letters, Elsevier, 2003, 44 (37), pp.7011-7013. ⟨10.1016/S0040-4039(03)01792-1⟩. ⟨hal-02385515⟩

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