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Journal articles
Synthesis of (3S, 4S)-4-hydroxy-2, 3, 4, 5-tetrahydropyridazine-3-carboxylic acid, component of luzopeptin A.
Abstract : The enantioselective synthesis of (3S, 4S)-4-hydroxy-2, 3, 4, 5-tetrahydropyridazine-3-carboxylic acid 1 is described. The two stereogenic centers in anti relationship are obtained by sequential enantio and chemoselective hydrogenation of β-ketoester in presence of chiral ruthenium catalyst and diastereoselective amination of β-hydroxyester with di t-butylazodicarboxylate.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02385502
Contributor : Laurent Bischoff Connect in order to contact the contributor
Submitted on : Thursday, November 28, 2019 - 6:43:47 PM
Last modification on : Tuesday, September 22, 2020 - 3:38:23 AM
Contributor : Laurent Bischoff Connect in order to contact the contributor
Submitted on : Thursday, November 28, 2019 - 6:43:47 PM
Last modification on : Tuesday, September 22, 2020 - 3:38:23 AM
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