One-Pot Synthesis of 2,3-Dihydro-pyrrolopyridinones Using in Situ Generated Formimines

Geoffrey Deguest (1) , Laurent Bischoff (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

A novel one-pot methodology is described for the synthesis of functionalized pyrrolopyridinones using in situ generated formimines and an ortho-lithiated pyridinecarboxamide species. Depending on the reaction conditions, this procedure allows versatile access to aminomethylated pyridinecarboxamides, 2,3-dihydro-pyrrolopyridinones, or 1,1-dialkylated 2,3-dihydro-pyrrolopyridinone derivatives.

Domaines: Chimie; Chimie organique; Chimie thérapeutique; Radiochimie; Matériaux; Chimie inorganique; Catalyse

Geoffrey Deguest, Laurent Bischoff. One-Pot Synthesis of 2,3-Dihydro-pyrrolopyridinones Using in Situ Generated Formimines. Organic Letters, 2007, 9 (3), pp.545-545. ⟨10.1021/ol063033d⟩. ⟨hal-02385488⟩