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On the racemisation of aspartic anhydride during its preparation

Abstract : Due to the possible differentiation of both carboxyl groups, N-protected aspartic anhydride is a useful starting material in synthesis. However, most methods published in the literature for its formation lead to partial racemisation, which is generally not mentioned. Herein we report a comparison between the main methods published, with accurate measurements of the enantiomeric purity of this compound.
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Submitted on : Thursday, November 28, 2019 - 4:03:51 PM
Last modification on : Thursday, July 2, 2020 - 3:29:28 AM

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Frédéric Buron, Geoffrey Deguest, Laurent Bischoff, Corinne Fruit, Francis Marsais. On the racemisation of aspartic anhydride during its preparation. Tetrahedron: Asymmetry, Elsevier, 2007, 18 (13), pp.1625-1627. ⟨10.1016/j.tetasy.2007.07.003⟩. ⟨hal-02385023⟩

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