Aminoacid-derived mercaptoimidazoles

Alain Crépin , Nicolas Wattier (1) , Sylvain Petit (2) , Laurent Bischoff (1) , Corinne Fruit (1) , Francis Marsais (3)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 GDI - Gouvernance et développement insulaire
3 IRCOF - Institut de Chimie Organique Fine

Starting from suitably protected aminoacids, mercaptoimidazoles were synthesized either from the acid or including the amine nitrogen itself. A preliminary optimisation study led to efficient conditions for the obtention of the imidazole ring. These conditions are compatible with the presence of aminoacid or dipeptide scaffolds.

Domains: Chemical Sciences; Chemical Sciences; Organic chemistry; Chemical Sciences; Medicinal Chemistry; Chemical Sciences; Radiochemistry; Chemical Sciences; Material chemistry; Chemical Sciences; Inorganic chemistry; Chemical Sciences; Catalysis

Alain Crépin, Nicolas Wattier, Sylvain Petit, Laurent Bischoff, Corinne Fruit, et al.. Aminoacid-derived mercaptoimidazoles. Organic & Biomolecular Chemistry, 2009, 7 (1), pp.128-134. ⟨10.1039/B810678A⟩. ⟨hal-02384993⟩