Synthesis of pyridylglyoxylic acid derivatives via a palladium-catalysed double carbonylation of iodopyridines

Samuel Couve-Bonnaire (1) , Jean-François Carpentier (1) , Yves Castanet (1) , Andre Mortreux (1)

1 UCCS - Unité de Catalyse et Chimie du Solide - UMR 8181

4-Iodopyridiens react with CO and HNEt2 or in the presence of a catalytic amount of PdCl2(PPh3)2 to give the corresponding α-keto amides and esters in fair to high yields. 4-iodopyridines are transformed into the corresponding α-keto amides and esters in moderate to high yields.

Domains: Chemical Sciences; Catalysis; Chemical Sciences; Coordination chemistry; Chemical Sciences; Inorganic chemistry; Chemical Sciences; Organic chemistry; Chemical Sciences; Theoretical and/or physical chemistry; Chemical Sciences; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Life Sciences [q-bio]; Cancer; Life Sciences [q-bio]

Samuel Couve-Bonnaire, Jean-François Carpentier, Yves Castanet, Andre Mortreux. Synthesis of pyridylglyoxylic acid derivatives via a palladium-catalysed double carbonylation of iodopyridines. Tetrahedron Letters, 1999, 40 (19), pp.3717-3718. ⟨10.1016/S0040-4039(99)00596-1⟩. ⟨hal-02384504⟩