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Journal articles
Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis
Abstract : Due to the growing interest in small molecules that could help in understanding protein-protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has grown significantly. Many of these pathways are highly complex and present tremendous challenges with the use of classical tools. A rapid access to natural product-like small molecules having structural complexity and diversity is crucial for systematically dissecting the functions of complex protein networking and understanding cell signaling pathways. The complex nature, the three-dimensional architecture, and the number of protein binding functional groups presented in three-dimensional arrays are some of the attractive features to incorporate in smallmolecule chemical probes to be used as modulators of protein function.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02384483
Contributor : samuel couve-bonnaire Connect in order to contact the contributor
Submitted on : Thursday, November 28, 2019 - 1:49:59 PM
Last modification on : Wednesday, April 15, 2020 - 11:26:02 AM
Contributor : samuel couve-bonnaire Connect in order to contact the contributor
Submitted on : Thursday, November 28, 2019 - 1:49:59 PM
Last modification on : Wednesday, April 15, 2020 - 11:26:02 AM
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