Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis - Archive ouverte HAL Access content directly
Journal Articles Pure and Applied Chemistry Year : 2005

Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis

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Abstract

Due to the growing interest in small molecules that could help in understanding protein-protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has grown significantly. Many of these pathways are highly complex and present tremendous challenges with the use of classical tools. A rapid access to natural product-like small molecules having structural complexity and diversity is crucial for systematically dissecting the functions of complex protein networking and understanding cell signaling pathways. The complex nature, the three-dimensional architecture, and the number of protein binding functional groups presented in three-dimensional arrays are some of the attractive features to incorporate in smallmolecule chemical probes to be used as modulators of protein function.

Dates and versions

hal-02384483 , version 1 (28-11-2019)

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P. Arya, S. Quevillon, R. Joseph, C.-Q. Wei, Z. Gan, et al.. Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis. Pure and Applied Chemistry, 2005, 77 (1), pp.163-178. ⟨10.1351/pac200577010163⟩. ⟨hal-02384483⟩

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