Synthesis of tetrasubstituted α-fluoroenones

Guillaume Dutheuil (1) , Samuel Couve-Bonnaire (1) , Xavier Pannecoucke (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

We reported the synthesis of tetrasubstituted α-fluoroenones from tetrasubstituted gem-bromofluoroolefins in good yields. These compounds are scarcely studied in the literature, due to difficulty of synthesis, whereas they could serve as intermediates in the synthesis of biological relevant molecules and could also be envisioned to design new constrained peptidomimetics.

Domains: Chemical Sciences; Catalysis; Chemical Sciences; Coordination chemistry; Chemical Sciences; Inorganic chemistry; Chemical Sciences; Organic chemistry; Chemical Sciences; Theoretical and/or physical chemistry; Chemical Sciences; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Life Sciences [q-bio]; Cancer; Life Sciences [q-bio]

Guillaume Dutheuil, Samuel Couve-Bonnaire, Xavier Pannecoucke. Synthesis of tetrasubstituted α-fluoroenones. Tetrahedron, 2009, 65 (31), pp.6034-6038. ⟨10.1016/j.tet.2009.05.065⟩. ⟨hal-02384412⟩