Conception of DYRK1A kinase inhibitors via metal-catalyzed C-H arylation, inspired by fragment-growing studies

Florence Couly (1) , Julien Diharce (2) , Pascal Bonnet (2) , Meijer Laurent (3) , Corinne Fruit (1) , Thierry Besson (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 ICOA - Institut de Chimie Organique et Analytique
3 ManRos Therapeutics

Domains: Chemical Sciences

Florence Couly, Julien Diharce, Pascal Bonnet, Meijer Laurent, Corinne Fruit, et al.. Conception of DYRK1A kinase inhibitors via metal-catalyzed C-H arylation, inspired by fragment-growing studies. International Electronic Conference on Medicinal Chemistry (ECMC, 4, 2018), Jean-Jacques Vanden Eynde (coord.), Nov 2018, [online], Belgium. ⟨10.3390/ecmc-4-05580⟩. ⟨hal-02383907⟩