Organocatalytic Radical and Electron Transfer Reactions

Thibault Gallavardin (1) , Peter Dalko (1)

1 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques

Open shell (radical and radical ionic) reactions are distinguished by complementary chemoselectivity compared to ionic (closed‐shell) reactions. Conditions for synthetically useful asymmetric intra‐ and intermolecular α‐alkylation, allylation, arylation, fluoroalkylation, and heteroatom functionalization of carbonyl compounds have emerged via electron‐transfer mediated reactions, including oxidative conditions, redox photoreactions, and purely photochemical approaches.

Keywords: radical reactions; alkylation; allylation; arrylation; fluoralkylation; heteroatom functionnalization; carbonyl compounds; redox reactions; photochemistry

Domains: Chemical Sciences; Chemical Sciences; Organic chemistry

Thibault Gallavardin, Peter Dalko. Organocatalytic Radical and Electron Transfer Reactions. Comprehensive Enantioselective Organocatalysis, Wiley-VCH Verlag GmbH & Co. KGaA, pp.1163-1190, 2013, 9783527332366. ⟨10.1002/9783527658862.ch39⟩. ⟨hal-02383458⟩