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From One-Photon to Two-Photon Probes: “Caged” Compounds, Actuators, and Photoswitches

Guillaume Bort 1 Thibault Gallavardin 1 David Ogden 2 Peter Dalko 1
1 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
2 LPC - UMR 8118 - Laboratoire de physiologie cérébrale
Abstract : Molecular systems that can be remotely controlled by light are gaining increasing importance in cell biology, physiology, and neurosciences because of the spatial and temporal precision that is achievable with laser microscopy. Two‐photon excitation has significant advantages deep in biological tissues, but raises problems in the design of “smart” probes compatible with cell physiology. This Review discusses the chemical challenges in generating suitable two‐photon probes.
Keywords : caged compounds cell signaling photochemistry protecting groups signal transduction
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02383418
Contributor : Thibault Gallavardin <>
Submitted on : Wednesday, November 27, 2019 - 5:11:54 PM
Last modification on : Monday, April 20, 2020 - 11:00:02 AM

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Guillaume Bort, Thibault Gallavardin, David Ogden, Peter Dalko. From One-Photon to Two-Photon Probes: “Caged” Compounds, Actuators, and Photoswitches. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2013, 52 (17), pp.4526-4537. ⟨10.1002/anie.201204203⟩. ⟨hal-02383418⟩

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