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Short Communication: Characterization of a New HIV-1 Group N Isolate Originating from a Cameroonian Patient

Paul Alain Tagnouokam Ngoupo 1 Serge Alain Sadeuh-Mba 1 Fabienne de Oliveira 2, 3 Elodie Téclaire Ngo-Malabo 1 Laure Ngono 1 Jean-Christophe Plantier 2, 3 Anfumbom Kfutwah 1 Richard Njouom 1
1 Centre Pasteur du Cameroun
2 GRAM 2.0 - Groupe de Recherche sur l'Adaptation Microbienne
3 Laboratoire de virologie [Rouen]
Abstract : HIV-1 group N (HIV-1/N) remains rare and mainly restricted to Cameroon. In this study, we report a new HIV-1/N infected case identified during routine HIV screening activities in Yaounde. The genetic characterization of the near full-length genome of this virus strain revealed that it is genetically distinct to all HIV-1/N described to date. However, the Vpu protein responsible for tetherin antagonism displayed the same amino acid substitutions (E15A, V19A, I25L, and V26L) as other HIV-1/N from Cameroon.
Keywords : Cameroon HIV-1 group N Vpu protein epidemiology tetherin
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02383284
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Submitted on : Wednesday, November 27, 2019 - 4:25:49 PM
Last modification on : Wednesday, March 2, 2022 - 4:18:04 PM

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COMUE-NORMANDIE | RIIP_CAMEROUN | RIIP | UNIROUEN | UNICAEN | GRAM

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Paul Alain Tagnouokam Ngoupo, Serge Alain Sadeuh-Mba, Fabienne de Oliveira, Elodie Téclaire Ngo-Malabo, Laure Ngono, et al.. Short Communication: Characterization of a New HIV-1 Group N Isolate Originating from a Cameroonian Patient. AIDS Research and Human Retroviruses, Mary Ann Liebert, 2018, 34 (7), pp.621-625. ⟨10.1089/AID.2018.0015⟩. ⟨hal-02383284⟩

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