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New HIV-1 circulating recombinant form 94: from phylogenetic detection of a large transmission cluster to prevention in the age of geosocial-networking apps in France, 2013 to 2017

Marc Wirden 1 Fabienne de Oliveira 2, 3 Magali Bouvier-Alias 4 Sidonie Lambert-Niclot 5 Marie-Laure Chaix 6 Stéphanie Raymond 7 Ali Si-Mohammed 8 Chakib Alloui 9 Elisabeth André-Garnier 10 Pantxika Bellecave 11 Brice Malve 12 Audrey Mirand 13 Coralie Pallier 14 Jean-Dominique Poveda 15 Theresa Rabenja 16 Véronique Schneider 17 Anne Signori-Schmuck 18 Karl Stefic 19 Vincent Calvez 20 Diane Descamps 21, 22 Jean-Christophe Plantier 2, 3 Anne-Geneviève Marcelin 20 Benoit Visseaux 22, 21
1 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
2 GRAM 2.0 - Groupe de Recherche sur l'Adaptation Microbienne
3 Laboratoire de virologie [Rouen]
4 Hôpital Henri Mondor
5 Laboratoire de Virologie [CHU Saint-Antoine]
6 Laboratoire de Virologie [CHU Saint-Louis]
7 Laboratoire de Virologie [Toulouse]
8 CNR virus entériques - Centre National de Référence des virus entériques [CHU de Dijon]
9 Service de bactériologie-Virologie-Hygiène [Avicenne]
10 Service de virologie [CHU Nantes]
11 Service de virologie et unité de surveillance biologique [Bordeaux]
12 Service de Virologie [CHRU Nancy]
13 LMGE - Laboratoire Microorganismes : Génome et Environnement - Clermont Auvergne
14 Service de Virologie [Villejuif]
15 Laboratoire CERBA [Saint Ouen l'Aumône]
16 GHEF - Grand Hôpital de l'Est Francilien
17 Service de virologie [Hôpital Tenon]
18 Département de virologie [Grenoble]
19 Service de bactériologie-virologie [Tours]
20 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
21 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
22 Service de Virologie [CHU Bichat]
Abstract : Background Ending the HIV pandemic must involve new tools to rapidly identify and control local outbreaks and prevent the emergence of recombinant strains with epidemiological advantages. Aim This observational study aimed to investigate in France a cluster of HIV-1 cases related to a new circulating recombinant form (CRF). The confirmation this CRF’s novelty as well as measures to control its spread are presented. Methods Phylogenetic analyses of HIV sequences routinely generated for drug resistance genotyping before 2018 in French laboratories were employed to detect the transmission chain. The CRF involved was characterised by almost full-length viral sequencing for six cases. Cases’ clinical data were reviewed. Where possible, epidemiological information was collected with a questionnaire. Results The transmission cluster comprised 49 cases, mostly diagnosed in 2016–2017 (n = 37). All were infected with a new CRF, CRF94_cpx. The molecular proximity of this CRF to X4 strains and the high median viraemia, exceeding 5.0 log10 copies/mL, at diagnosis, even in chronic infection, raise concerns of enhanced virulence. Overall, 41 cases were diagnosed in the Ile-de-France region and 45 were men who have sex with men. Among 24 cases with available information, 20 reported finding partners through a geosocial networking app. Prevention activities in the area and population affected were undertaken. Conclusion We advocate the systematic use of routinely generated HIV molecular data by a dedicated reactive network, to improve and accelerate targeted prevention interventions. Geosocial networking apps can play a role in the spread of outbreaks, but could also deliver local targeted preventive alerts.
Keywords : HIV cluster HIV CRF94 phylogenetic analysis HIV Outbreak HIV Prevention
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Journal articles
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02383043
Contributor : Sandy Mzembaba <>
Submitted on : Wednesday, November 27, 2019 - 3:12:16 PM
Last modification on : Thursday, December 10, 2020 - 3:42:42 AM

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COMUE-NORMANDIE | LMGE | IPLESP | IAME | UNIV-PARIS13 | UNIROUEN | SORBONNE-UNIVERSITE | UNIV-PARIS7 | UNICAEN | SU-MEDECINE | GRAM | USPC | CNRS | PRES_CLERMONT | UPEC-UPEM | UPEC | UNIV-PARIS | UP-SANTE | SU-TI

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Marc Wirden, Fabienne de Oliveira, Magali Bouvier-Alias, Sidonie Lambert-Niclot, Marie-Laure Chaix, et al.. New HIV-1 circulating recombinant form 94: from phylogenetic detection of a large transmission cluster to prevention in the age of geosocial-networking apps in France, 2013 to 2017. Eurosurveillance, European Centre for Disease Prevention and Control, 2019, 24 (39), ⟨10.2807/1560-7917.ES.2019.24.39.1800658⟩. ⟨hal-02383043⟩

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