False-negative Results of Human Immunodeficiency Virus (HIV) Rapid Testing in HIV Controllers

Mehdi Hage-Sleiman (1) , Pauline Trémeaux (2, 3) , Marine Fillion (3) , Faroudy Boufassa (4, 5, 6) , Adeline Mélard (3) , Elise Gardiennet (3) , Alice-Andrée Mariaggi (3, 2) , Jean-Christophe Plantier (7, 8) , Christine Rouzioux (9, 10) , Olivier Lambotte (11, 12, 4) , Véronique Avettand-Fenoël (9, 3)

1 CHU Necker - Enfants Malades [AP-HP]
2 Service de Virologie [CHU Cochin]
3 IC UM3 (UMR 8104 / U1016) - Institut Cochin
4 UP11 - Université Paris-Sud - Paris 11
5 Université Paris-Saclay
6 CESP - Centre de recherche en épidémiologie et santé des populations
7 GRAM 2.0 - Groupe de Recherche sur l'Adaptation Microbienne
8 Laboratoire de virologie [Rouen]
9 Laboratoire de Virologie [CHU Necker]
10 UPD5 - Université Paris Descartes - Paris 5
11 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
12 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)

Serological assays were performed on 85 human immunodeficiency virus-controller samples . 6% presented a negative rapid screening test 7% presented an indeterminate Western blot. The enzyme immunoassay ratio decreased in controllers who had continual negative ultrasensitive HIV RNA results since inclusion.

Keywords: ELISA; HIV controllers; HIV diagnosis; HIV rapid screening test; HIV-1 Western blot

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Microbiology and Parasitology; Protistology; Life Sciences [q-bio]; Microbiology and Parasitology; Mycology; Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology

Mehdi Hage-Sleiman, Pauline Trémeaux, Marine Fillion, Faroudy Boufassa, Adeline Mélard, et al.. False-negative Results of Human Immunodeficiency Virus (HIV) Rapid Testing in HIV Controllers. Clinical Infectious Diseases, 2019, ⟨10.1093/cid/ciz734⟩. ⟨hal-02382971⟩