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Synthesis of 6-Substituted Pyrido[2,3- b ]indoles by Electrophilic Substitution

Abstract : Regioselective electrophilic aromatic substitutions, acylation, bromination, and formylation, of unprotected pyrido[2,3-b]indole (α-carbolines) at the C-6 position are described. Alter­native conditions for the nitration were investigated, which led to the ­unexpected appearance of the minor C-8 isomer.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02380611
Contributor : Cédric Schneider <>
Submitted on : Tuesday, November 26, 2019 - 12:22:15 PM
Last modification on : Saturday, July 11, 2020 - 3:17:06 AM

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Cédric Schneider, David Gueyrard, Florence Popowycz, Benoît Joseph, Peter Goekjian. Synthesis of 6-Substituted Pyrido[2,3- b ]indoles by Electrophilic Substitution. SYNLETT, Georg Thieme Verlag, 2007, 2007 (14), pp.2237-2241. ⟨10.1055/s-2007-985566⟩. ⟨hal-02380611⟩

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