Directed ortho -Metalation–Cross-Coupling Strategies. One-Pot Suzuki Reaction to Biaryl and Heterobiaryl Sulfonamides - Archive ouverte HAL Access content directly
Journal Articles Organic Letters Year : 2011

Directed ortho -Metalation–Cross-Coupling Strategies. One-Pot Suzuki Reaction to Biaryl and Heterobiaryl Sulfonamides

Abstract

A general synthesis of stable ortho-boropinacolato aryl and heteroaryl sulfonamides by directed ortho-metalation (DoM) and either MeOBPin or i-PrOBpin electrophile quench, 3 → 4, is described. A one-pot metalation–Suzuki cross-coupling procedure for the synthesis of biaryls and heterobiaryls, 3 → 5, and a complementary DoM–Ir-catalyzed boronation sequence (Scheme 6) are delineated.
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hal-02380533 , version 1 (26-11-2019)

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Cédric Schneider, Ellen Broda, Victor Snieckus. Directed ortho -Metalation–Cross-Coupling Strategies. One-Pot Suzuki Reaction to Biaryl and Heterobiaryl Sulfonamides. Organic Letters, 2011, 13 (14), pp.3588-3591. ⟨10.1021/ol201175g⟩. ⟨hal-02380533⟩
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