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Journal articles
In Situ Anionic Shielding for Regioselective Metalation: Directed peri and Iterative Metalation Routes to Polyfunctionalized 7-Azaindoles
Abstract : Strolling the ring: a general regioselective directed peri(C4)-metalation route to 1 through an in situ N-anionic protection of C2 is reported. The azaindoles may be elaborated by directed ortho metalation (DoM) and Suzuki coupling to more complex heterocyclic systems. An iterative ring-walk DoM sequence furnishes the exhaustively substituted 2. DMG=directed metalation group, TMEDA=N,N,N',N'-tetramethylethylenediamine, TMS=trimethylsilyl.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02380527
Contributor : Cédric Schneider <>
Submitted on : Tuesday, November 26, 2019 - 11:59:56 AM
Last modification on : Thursday, July 2, 2020 - 3:28:51 AM
Contributor : Cédric Schneider <>
Submitted on : Tuesday, November 26, 2019 - 11:59:56 AM
Last modification on : Thursday, July 2, 2020 - 3:28:51 AM
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