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Frameshift mutations, neoantigens and tumor-specific CD8 + T cells in microsatellite unstable colorectal cancers

Abstract : Microsatellite unstable colorectal cancers (CRC) express frameshift mutation-derived tumor-specific neoantigens. We recently showed that: (i) frameshift mutations were correlated with tumor-infiltrating CD8(+) T cell density, (ii) neoantigen-specific cytotoxic T cells could be obtained in patients whose tumors harbored these mutations, underlining the interest of developing personalized immunotherapy strategies in these cancers.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02379902
Contributor : Jean-Baptiste Latouche <>
Submitted on : Monday, November 25, 2019 - 10:43:09 PM
Last modification on : Friday, September 18, 2020 - 2:34:59 PM

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Pauline Maby, Jérôme Galon, Jean-Baptiste Latouche. Frameshift mutations, neoantigens and tumor-specific CD8 + T cells in microsatellite unstable colorectal cancers. OncoImmunology, Taylor & Francis, 2016, 5 (5), pp.e1115943. ⟨10.1080/2162402X.2015.1115943⟩. ⟨hal-02379902⟩

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