Frameshift mutations, neoantigens and tumor-specific CD8 + T cells in microsatellite unstable colorectal cancers

Pauline Maby; Jérôme Galon; Jean-Baptiste Latouche

doi:10.1080/2162402X.2015.1115943

Journal articles

Frameshift mutations, neoantigens and tumor-specific CD8 + T cells in microsatellite unstable colorectal cancers

Pauline Maby ¹ Jérôme Galon ^{2, 1} Jean-Baptiste Latouche ^{3, 4, 5}

1 UPD5 - Université Paris Descartes - Paris 5

2 CRC - Centre de Recherche des Cordeliers

3 GMFC - Génétique du cancer et des maladies neuropsychiatriques

4 PANTHER - Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices

5 CHU Rouen

Abstract : Microsatellite unstable colorectal cancers (CRC) express frameshift mutation-derived tumor-specific neoantigens. We recently showed that: (i) frameshift mutations were correlated with tumor-infiltrating CD8(+) T cell density, (ii) neoantigen-specific cytotoxic T cells could be obtained in patients whose tumors harbored these mutations, underlining the interest of developing personalized immunotherapy strategies in these cancers.

Keywords : Adoptive cell transfer colorectal cancer frameshift mutation immunotherapy microsatellite instablility neoantigen neopeptide tumor-specific CD8+ T cell

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-02379902
Contributor : Jean-Baptiste Latouche <>
Submitted on : Monday, November 25, 2019 - 10:43:09 PM
Last modification on : Friday, September 18, 2020 - 2:34:59 PM

Frameshift mutations, neoantigens and tumor-specific CD8 + T cells in microsatellite unstable colorectal cancers

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Frameshift mutations, neoantigens and tumor-specific CD8 + T cells in microsatellite unstable colorectal cancers

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