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Frameshift mutations, neoantigens and tumor-specific CD8 + T cells in microsatellite unstable colorectal cancers

Pauline Maby 1 Jérôme Galon 2, 1 Jean-Baptiste Latouche 3, 4, 5
1 UPD5 - Université Paris Descartes - Paris 5
2 CRC - Centre de Recherche des Cordeliers
3 GMFC - Génétique du cancer et des maladies neuropsychiatriques
4 PANTHER - Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices
5 CHU Rouen
Abstract : Microsatellite unstable colorectal cancers (CRC) express frameshift mutation-derived tumor-specific neoantigens. We recently showed that: (i) frameshift mutations were correlated with tumor-infiltrating CD8(+) T cell density, (ii) neoantigen-specific cytotoxic T cells could be obtained in patients whose tumors harbored these mutations, underlining the interest of developing personalized immunotherapy strategies in these cancers.
Keywords : Adoptive cell transfer colorectal cancer frameshift mutation immunotherapy microsatellite instablility neoantigen neopeptide tumor-specific CD8+ T cell
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02379902
Contributor : Jean-Baptiste Latouche <>
Submitted on : Monday, November 25, 2019 - 10:43:09 PM
Last modification on : Thursday, December 10, 2020 - 10:52:57 AM

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COMUE-NORMANDIE | UPMC | UNIV-PARIS5 | UNIROUEN | U1234PANTHER | SORBONNE-UNIVERSITE | UNIV-PARIS7 | CORDELIERS | EPHE | USPC | SU-SCIENCES | UNIV-PARIS | UP-SANTE | PSL | SU-TI

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Pauline Maby, Jérôme Galon, Jean-Baptiste Latouche. Frameshift mutations, neoantigens and tumor-specific CD8 + T cells in microsatellite unstable colorectal cancers. OncoImmunology, Taylor & Francis, 2016, 5 (5), pp.e1115943. ⟨10.1080/2162402X.2015.1115943⟩. ⟨hal-02379902⟩

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