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Journal Articles Journal of Fluorine Chemistry Year : 2007

First enantioselective reductive amination of α-fluoroenones

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1

Abstract

From α-fluoroenones 2, a synthesis of (E) ketone oxime O-alkyl ethers 5 is reported with good to excellent yields. Then the first enantioselective reduction of these ketimines, via oxazaborolidine, is described with moderate to good enantiomeric excesses, leading to valuable chiral fluoroallylic amines 1.

Dates and versions

hal-02378329 , version 1 (25-11-2019)

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Guillaume Dutheuil, Laëtitia Bailly, Samuel Couve-Bonnaire, Xavier Pannecoucke. First enantioselective reductive amination of α-fluoroenones. Journal of Fluorine Chemistry, 2007, 128 (1), pp.34-39. ⟨10.1016/j.jfluchem.2006.09.013⟩. ⟨hal-02378329⟩
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