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Germline Mutations of Inhibins in Early-Onset Ovarian Epithelial Tumors

Abstract : To identify novel genetic bases of early-onsetepithelial ovarian tumors, we used the trio exome sequencing strategy in a patient without familial history of cancerwho presented metastatic serous ovarian adenocarcinomasat 21 years of age. We identified a single de novo mutation(c.1157A>G/p.Asn386Ser) within the INHBA gene encoding the βA-subunit of inhibins/activins, which play akey role in ovarian development. In vitro, this mutation alters the ratio of secreted activins and inhibins. In a secondpatient with early-onset serous borderline papillary cystadenoma, we identified an unreported germline mutation(c.179G>T/p.Arg60Leu) of the INHA gene encoding theα-subunit, the partner of the βA-subunit. This mutationalso alters the secreted activin/inhibin ratio, by disruptingboth inhibin A and inhibin B biosynthesis. In a cohort of62 cases, we detected an additional unreported germlinemutation of the INHBA gene (c.839G>A/p.Gly280Glu).Our results strongly suggest that inhibin mutations contribute to the genetic determinism of epithelial ovariantumors.
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Submitted on : Thursday, May 27, 2021 - 2:31:13 PM
Last modification on : Wednesday, October 27, 2021 - 4:13:12 PM
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Isabelle Tournier, Régine Marlin, Kelly Walton, Francoise Charbonnier, Sophie Coutant, et al.. Germline Mutations of Inhibins in Early-Onset Ovarian Epithelial Tumors. Human Mutation, Wiley, 2014, 35 (3), pp.294-297. ⟨10.1002/humu.22489⟩. ⟨hal-02375836⟩



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