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Improvement of a Biomimetic Porphyrin Catalytic System by Addition of Acids

Abstract : The conditions of the use of the manganese/porphyrin/imidazole system needed to be improved in order to obtain larger amounts of models of metabolites. An increase of the oxidation yields and a better preservation of this catalytic system have been obtained on the examples of various alkanes, by an acid addition in the reaction mixture. Three manganoporphyrins were checked for evaluation of the reaction. These results were extended to molecules of therapeutical interest such as ibuprofen and phenylbutazone.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02375751
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Submitted on : Friday, November 22, 2019 - 10:44:19 AM
Last modification on : Thursday, July 2, 2020 - 3:30:02 AM

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Jérôme Segrestaa, Philippe Vérité, François Estour, Sabine Ménager, Olivier Lafont. Improvement of a Biomimetic Porphyrin Catalytic System by Addition of Acids. Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 2002, 50 (6), pp.744-748. ⟨10.1248/cpb.50.744⟩. ⟨hal-02375751⟩

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