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Synthesis and biological testing of 3-phenyloctahydro-pyrimido[1,2- a ]- s -triazine derivatives

Line Lucry 1 Ferdinand Enoma 1 François Estour 2, 3 Sabine Ménager 1 Olivier Lafont 1 Hassan Oulyadi 3
1 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
2 Secobra
3 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
Abstract : A series of 46 3‐phenyloctahydropyrimido[1,2‐a]‐s–triazine derivatives were synthesized. This synthesis was performed via iminodimethylation of dialkylated 2‐aminopyrimidinedione synthons by substituted primary arylamines. In vitro pharmacological evaluation of these compounds is reported. One of them exhibited antifungal activity against Microsporum canis (10−65010−5 mol/L), and another showed affinity for serotoninergic 5‐HT1A and 5‐HT2b receptors (10−85010−7 mol/L).
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02375741
Contributor : François Estour <>
Submitted on : Friday, November 22, 2019 - 10:40:10 AM
Last modification on : Thursday, July 2, 2020 - 3:29:39 AM

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COMUE-NORMANDIE | INC-CNRS | INSA-ROUEN | UNIROUEN | COBRA | INSA-GROUPE | CNRS | ENSICAEN | UNILEHAVRE | UNICAEN

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Line Lucry, Ferdinand Enoma, François Estour, Sabine Ménager, Olivier Lafont, et al.. Synthesis and biological testing of 3-phenyloctahydro-pyrimido[1,2- a ]- s -triazine derivatives. Journal of Heterocyclic Chemistry, Wiley, 2002, 39 (4), pp.663-670. ⟨10.1002/jhet.5570390410⟩. ⟨hal-02375741⟩

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