M. Salganik, M. L. Hirsch, and R. J. Samulski, Adeno-associated Virus as a Mammalian DNA Vector, Microbiol Spectr, vol.3, 2015.

R. Popa-wagner, Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry, J Virol, vol.86, pp.9163-9174, 2012.

F. Sonntag, S. Bleker, B. Leuchs, R. Fischer, and J. A. Kleinschmidt, Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus, J Virol, vol.80, pp.11040-11054, 2006.

Q. Xie, The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy, Proc Natl Acad Sci, vol.99, pp.10405-10410, 2002.

M. A. Dimattia, Structural Insight into the Unique Properties of Adeno-Associated Virus Serotype 9, Journal of Virology, vol.86, pp.6947-6958, 2012.

L. Govindasamy, Structurally mapping the diverse phenotype of adeno-associated virus serotype 4, J Virol, vol.80, pp.11556-11570, 2006.

B. L. Gurda, Capsid antibodies to different adeno-associated virus serotypes bind common regions, J Virol, vol.87, pp.9111-9124, 2013.

B. L. Gurda, Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8, J Virol, vol.86, pp.7739-7751, 2012.

H. J. Nam, Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking, J Virol, vol.85, pp.11791-11799, 2011.

R. Ng, Structural characterization of the dual glycan binding adeno-associated virus serotype 6, J Virol, vol.84, pp.12945-12957, 2010.

Y. S. Tseng and M. Agbandje-mckenna, Mapping the AAV Capsid Host Antibody Response toward the Development of Second Generation Gene Delivery Vectors, Front Immunol, vol.5, 2014.

K. Jooss, Y. Yang, K. J. Fisher, and J. M. Wilson, Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers, J Virol, vol.72, pp.4212-4223, 1998.

J. Zhu, X. Huang, and Y. Yang, The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice, J Clin Invest, vol.119, pp.2388-2398, 2009.

K. Nieto and A. Salvetti, AAV Vectors Vaccines Against Infectious Diseases, Front Immunol, vol.5, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00965088

P. Colella, G. Ronzitti, and F. Mingozzi, Emerging Issues in AAV-Mediated In Vivo Gene Therapy, Mol Ther Methods Clin Dev, vol.8, pp.87-104, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01812088

A. Alloatti, F. Kotsias, J. G. Magallhaes, and S. Amigorena, Dendritic cell maturation and cross-presentation: timing matters!, Immunological Reviews, vol.272, pp.97-108, 2016.

M. Merad, P. Sathe, J. Helft, J. Miller, and A. Mortha, The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting, Annu Rev Immunol, vol.31, pp.563-604, 2013.

B. Pulendran, The varieties of immunological experience: of pathogens, stress, and dendritic cells, Annu Rev Immunol, vol.33, pp.563-606, 2015.

A. Savina and S. Amigorena, Phagocytosis and antigen presentation in dendritic cells, Immunol Rev, vol.219, pp.143-156, 2007.

G. L. Rogers, Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8(+) T cells, Blood, vol.129, pp.3184-3195, 2017.

J. Pandya, L. Ortiz, C. Ling, A. E. Rivers, and G. Aslanidi, Rationally designed capsid and transgene cassette of AAV6 vectors for dendritic cell-based cancer immunotherapy, Immunol Cell Biol, vol.92, pp.116-123, 2014.

S. Uhrig, Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis, Gene Ther, vol.19, pp.210-218, 2012.

L. Perabo, In vitro selection of viral vectors with modified tropism: the adeno-associated virus display, Mol Ther, vol.8, pp.151-157, 2003.

A. Kern, Identification of a heparin-binding motif on adeno-associated virus type 2 capsids, J Virol, vol.77, pp.11072-11081, 2003.

S. R. Opie, K. H. Warrington, M. Agbandje-mckenna, S. Zolotukhin, and N. Muzyczka, Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding, J Virol, vol.77, pp.6995-7006, 2003.

L. Perabo, Heparan sulfate proteoglycan binding properties of adeno-associated virus retargeting mutants and consequences for their in vivo tropism, J Virol, vol.80, pp.7265-7269, 2006.

J. Sallach, Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy, Mol Ther, vol.22, pp.929-939, 2014.

K. C. Mccullough, N. Ruggli, and A. Summerfield, Dendritic cells-at the front-line of pathogen attack, Vet Immunol Immunopathol, vol.128, pp.7-15, 2009.

A. Francois, Accurate Titration of Infectious AAV Particles Requires Measurement of Biologically Active Vector Genomes and Suitable Controls, Mol Ther Methods Clin Dev, vol.10, pp.223-236, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-01858411

B. C. Schnepp, K. R. Clark, D. L. Klemanski, C. A. Pacak, and P. R. Johnson, Genetic fate of recombinant adeno-associated virus vector genomes in muscle, J Virol, vol.77, pp.3495-3504, 2003.

X. Li, J. Zhao, Q. Yuan, and N. Xia, Detection of HBV Covalently Closed Circular DNA, Viruses, vol.9, 2017.

C. E. Thomas, T. A. Storm, Z. Huang, and M. A. Kay, Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors, J Virol, vol.78, pp.3110-3122, 2004.

E. D. Horowitz, Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release, J Virol, vol.87, pp.2994-3002, 2013.

J. Bernaud, Characterization of AAV vector particle stability at the single-capsid level, J Biol Phys, vol.44, pp.181-194, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01974270

S. Adriouch, Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer, Front Microbiol, vol.2, 2011.

R. Hardet, Oral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector, Mol Ther, vol.24, pp.87-95, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02377462

M. Dalod, R. Chelbi, B. Malissen, and T. Lawrence, Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming, EMBO J, vol.33, pp.1104-1116, 2014.

S. E. Autenrieth, Profiling of primary peripheral blood-and monocyte-derived dendritic cells using monoclonal antibodies from the HLDA10 Workshop in Wollongong, Australia. Clin Transl Immunology, vol.4, 2015.

K. Schinnerling, P. Garcia-gonzalez, and J. C. Aguillon, Gene expression profiling of human monocyte-derived dendritic cellssearching for molecular regulators of tolerogenicity, frontiers in Immunology, vol.6, 2015.

C. Hotta, H. Fujimaki, M. Yoshinari, M. Nakazawa, and M. Minami, The delivery of an antigen from the endocytic compartment into the cytosol for cross-presentation is restricted to early immature dendritic cells, Immunology, vol.117, pp.97-107, 2006.

Y. Wegrowski, Cell surface proteoglycan expression during maturation of human monocytes-derived dendritic cells and macrophages, Clin Exp Immunol, vol.144, pp.485-493, 2006.

C. Summerford, J. S. Bartlett, and R. J. Samulski, AlphaVbeta5 integrin a co-receptor for adeno-associated virus type 2 infection, Nature Medicine, vol.5, pp.78-82, 1999.

H. C. Levy, Heparin binding induces conformational changes in Adeno-associated virus serotype 2, J Struct Biol, vol.165, pp.146-156, 2009.

J. O'donnell, K. A. Taylor, and M. S. Chapman, Adeno-associated virus-2 and its primary cellular receptor-Cryo-EM structure of a heparin complex, Virology, vol.385, pp.434-443, 2009.

H. Buning, A. Huber, L. Zhang, N. Meumann, and U. Hacker, Engineering the AAV capsid to optimize vector-host-interactions, Curr Opin Pharmacol, vol.24, pp.94-104, 2015.

S. Sandgren, F. Cheng, and M. Belting, Nuclear targeting of macromolecular polyanions by an HIV-Tat derived peptide. Role for cellsurface proteoglycans, J Biol Chem, vol.277, pp.38877-38883, 2002.

M. D. Stewart and R. D. Sanderson, Heparan sulfate in the nucleus and its control of cellular functions, Matrix Biol, vol.35, pp.56-59, 2014.

U. Greber, Signalling in viral entry, Cell. Mol. Life Sci, vol.59, pp.608-626, 2002.

M. Nonnenmacher and T. Weber, Adeno-Associated Virus 2 Infection Requires Endocytosis through the CLIC/GEEC Pathway, Cell Host & Microbe, vol.10, pp.563-576, 2011.

M. Nonnenmacher and T. Weber, Intracellular transport of recombinant adeno-associated virus vectors, Gene Therapy, pp.1-10, 2012.

J. W. Flatt and U. F. Greber, Viral mechanisms for docking and delivering at nuclear pore complexes, Semin Cell Dev Biol, vol.68, pp.59-71, 2017.

A. Girod, The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity, J Gen Virol, vol.83, pp.973-978, 2002.

S. Stahnke, Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles, Virology, vol.409, pp.77-83, 2011.

A. Savina, NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells, Cell, vol.126, pp.205-218, 2006.

S. B. Drutman and E. S. Trombetta, Dendritic cells continue to capture and present antigens after maturation in vivo, J Immunol, vol.185, pp.2140-2146, 2010.

C. Langlet, CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization, J Immunol, vol.188, pp.1751-1760, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00685822

L. Arnold, Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis, J Exp Med, vol.204, pp.1057-1069, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00136917

A. Ghenassia, Intradermal Immunization with rAAV1 Vector Induces Robust Memory CD8(+) T Cell Responses Independently of Transgene Expression in DCs, Mol Ther, vol.25, pp.2309-2322, 2017.

S. A. Nicklin, Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells, Mol Ther, vol.4, pp.174-181, 2001.

A. Salvetti, Factors influencing recombinant adeno-associated virus production, Hum Gene Ther, vol.9, pp.695-706, 1998.

S. Zolotukhin, Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors, Methods, vol.28, pp.158-167, 2002.

N. Alazard-dany, Definition of herpes simplex virus type 1 helper activities for adeno-associated virus early replication events, PLoS Pathog, vol.5, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00425125

A. Wistuba, A. Kern, S. Weger, D. Grimm, and J. A. Kleinschmidt, Subcellular compartmentalization of adeno-associated virus type 2 assembly, J Virol, vol.71, pp.1341-1352, 1997.