X. Y. Cui, G. Skretting, Y. Jing, H. Sun, P. M. Sandset et al., Hypoxia influences stem cell-like properties in multidrug resistant K562 leukemic cells, Blood Cells Mol Dis, vol.51, pp.177-84, 2013.

X. Liu, Y. Su, H. Zhu, J. Cao, W. Ding et al., HIF-1?-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia, Pharmacol Res Off J Ital Pharmacol Soc, vol.62, pp.416-441, 2010.

J. Benito, Y. Shi, B. Szymanska, H. Carol, I. Boehm et al., Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104, PLoS One, vol.6, 2011.

K. Rouault-pierre, L. Lopez-onieva, K. Foster, F. Anjos-afonso, I. Lamrissi-garcia et al., HIF-2? protects human hematopoietic stem/ progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic reticulum stress, Cell Stem Cell, vol.13, pp.549-63, 2013.

W. R. Wilson and M. P. Hay, Targeting hypoxia in cancer therapy, Nat Rev Cancer, vol.11, pp.393-410, 2011.

P. J. Houghton, R. Lock, H. Carol, C. L. Morton, D. Phelps et al., Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program, Pediatr Blood Cancer, vol.57, pp.443-53, 2011.

O. Frolova, I. Samudio, J. M. Benito, R. Jacamo, S. M. Kornblau et al., Regulation of HIF-1? signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment, Cancer Biol Ther, vol.13, pp.858-70, 2012.

G. L. Semenza, Regulation of metabolism by hypoxia-inducible factor 1, Cold Spring Harb Symp Quant Biol, vol.76, pp.347-53, 2011.

B. Keith, R. S. Johnson, and M. C. Simon, HIF1? and HIF2?: sibling rivalry in hypoxic tumour growth and progression, Nat Rev Cancer, vol.12, pp.9-22, 2012.

J. Ribera and A. Oriol, Acute lymphoblastic leukemia in adolescents and young adults, Hematol Oncol Clin North Am, vol.23, pp.1033-1075, 2009.

G. Kaspers, J. Wijnands, R. Hartmann, L. Huismans, A. H. Loonen et al., Immunophenotypic cell lineage and in vitro cellular drug resistance in childhood relapsed acute lymphoblastic leukaemia, Eur J Cancer Oxf Engl, vol.41, pp.1300-1303, 2005.

J. Szczepanek, J. Styczy?ski, O. Haus, A. Tretyn, and M. Wysocki, Relapse of acute lymphoblastic leukemia in children in the context of microarray analyses, Arch Immunol Ther Exp, vol.59, pp.61-69, 2011.

R. W. Stam, D. Boer, M. L. Schneider, P. De-boer, J. Hagelstein et al., Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia, Blood, vol.115, pp.1018-1043, 2010.

G. Wei, D. Twomey, J. Lamb, K. Schlis, J. Agarwal et al., Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance, Cancer Cell, vol.10, pp.331-373, 2006.

A. Holleman, M. H. Cheok, M. L. Den-boer, Y. W. Veerman, A. Kazemier et al., Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment, N Engl J Med, vol.351, pp.533-575, 2004.

X. Cheng, R. L. Bennett, X. Liu, M. Byrne, and M. W. Stratford, PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis, Blood Cancer J, vol.3, p.144, 2013.

T. Wang, X. Shi, Y. Cong, S. Wang, Y. Wang et al., Reversal of multidrug resistance by 5,5?-dimethoxylariciresinol-4-O-?-D-glucoside in doxorubicin-resistant human leukemia K562/DOX, Indian J Pharmacol, vol.45, pp.597-602, 2013.

Y. Huang, M. L. Frazier, N. Zhang, Q. Liu, and C. Wei, Reverse-phase protein array analysis to identify biomarker proteins in human pancreatic cancer, Dig Dis Sci, vol.59, pp.968-75, 2014.

S. Broutin, F. Commo, D. Koning, L. , M. et al., Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array, Thyroid Off J Am Thyroid Assoc, vol.24, pp.43-51, 2014.

P. Koufopantelis, S. Georgakakou, M. Kazanis, C. Giaginis, A. Margeli et al., Direct injection liquid chromatography/positive ion electrospray ionization mass spectrometric quantification of methotrexate, folinic acid, folic acid and ondansetron in human serum, J Chromatogr B Analyt Technol Biomed Life Sci, vol.877, pp.3850-3856, 2009.

T. A. De-beaumais and E. Jacqz-aigrain, Intracellular disposition of methotrexate in acute lymphoblastic leukemia in children, Curr Drug Metab, vol.13, pp.822-856, 2012.

C. H. Takimoto, New antifolates: pharmacology and clinical applications, Oncologist, vol.1, pp.68-81, 1996.

G. J. Kaspers, R. Pieters, C. H. Van-zantwijk, E. R. Van-wering, . Van-der-does-van-den et al., Prednisolone resistance in childhood acute lymphoblastic leukemia: vitro-vivo correlations and cross-resistance to other drugs, Blood, vol.92, pp.259-66, 1998.

I. M. Ariës, I. S. Jerchel, R. Van-den-dungen, L. Van-den-berk, J. M. Boer et al., EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion, Leukemia, vol.28, pp.1828-1865, 2014.

C. Loebke, H. Sueltmann, C. Schmidt, F. Henjes, S. Wiemann et al., Infrared-based protein detection arrays for quantitative proteomics, Proteomics, vol.7, pp.558-64, 2007.

P. K. Smith, R. I. Krohn, G. T. Hermanson, A. K. Mallia, F. H. Gartner et al., Measurement of protein using bicinchoninic acid, Anal Biochem, vol.150, pp.76-85, 1985.

Z. Li, G. S. Koh, Y. Lu, S. Kham, and A. Yeoh, Vincristine and prednisolone combination reduces MDR1 and microenvironment-mediated treatment resistance in acute lymphoblastic leukemia, Blood, vol.122, p.2529, 2013.

P. S. Bachmann, R. Gorman, R. A. Papa, J. E. Bardell, J. Ford et al., Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia, Cancer Res, vol.67, pp.4482-90, 2007.

E. Klumper, R. Pieters, A. J. Veerman, D. R. Huismans, A. H. Loonen et al., In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia, Blood, vol.86, pp.3861-3869, 1995.

I. M. Ariës, B. R. Hansen, T. Koch, R. Van-den-dungen, W. E. Evans et al., The synergism of MCL1 and glycolysis on pediatric acute lymphoblastic leukemia cell survival and prednisolone resistance, Haematologica, vol.98, pp.1905-1916, 2013.

K. L. Silva, P. S. De-souza, G. De-moraes, A. Moellmann-coelho, C. Vasconcelos-f-da et al., XIAP and P-glycoprotein co-expression is related to imatinib resistance in chronic myeloid leukemia cells, Leuk Res, vol.37, pp.1350-1358, 2013.

D. Campana, E. Coustan-smith, A. Manabe, M. Buschle, S. C. Raimondi et al., Prolonged survival of B-lineage acute lymphoblastic leukemia cells is accompanied by overexpression of bcl-2 protein, Blood, vol.81, pp.1025-1056, 1993.

S. Qinghong, G. Shen, S. Lina, Z. Yueming, L. Xiaoou et al., Comparative proteomics analysis of differential proteins in respond to doxorubicin resistance in myelogenous leukemia cell lines, Proteome Sci, vol.13, p.1, 2015.

H. Yang, Q. Zhang, J. He, and W. Lu, Regulation of calcium signaling in lung cancer, J Thorac Dis, vol.2, pp.52-58, 2010.

I. Belichenko, N. Morishima, and D. Separovic, Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in jurkat cells, Arch Biochem Biophys, vol.390, pp.57-63, 2001.

X. Zhai, J. Lu, Y. Wang, F. Fang, B. Li et al., Reversal effect of bufalin on multidrug resistance in K562/VCR vincristine-resistant leukemia cell line, J Tradit Chin Med Chung Tsa Chih Ying Wen Pan Spons -China Assoc Tradit Chin Med Acad Tradit Chin Med, vol.34, pp.678-83, 2014.

Y. Nefedova, T. H. Landowski, and W. S. Dalton, Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms, Leukemia, vol.17, pp.1175-82, 2003.

S. Iwamoto, K. Mihara, J. R. Downing, C. Pui, and D. Campana, Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase, J Clin Invest, vol.117, pp.1049-57, 2007.

M. Ková?, M. Vá?ková, D. Petrá?ková, V. Pelková, E. Mejst?íková et al., Cytokines, growth, and environment factors in bone marrow plasma of acute lymphoblastic leukemia pediatric patients, Eur Cytokine Netw, vol.25, pp.8-13, 2014.

T. Matsunaga, N. Takemoto, T. Sato, R. Takimoto, I. Tanaka et al., Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia, Nat Med, vol.9, pp.1158-65, 2003.

P. Eliasson, M. Rehn, P. Hammar, P. Larsson, O. Sirenko et al., Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture, Exp Hematol, vol.38, pp.301-311, 2010.

K. Takubo, N. Goda, W. Yamada, H. Iriuchishima, E. Ikeda et al., Regulation of the HIF-1alpha level is essential for hematopoietic stem cells, Cell Stem Cell, vol.7, pp.391-402, 2010.

M. C. Simon and B. Keith, The role of oxygen availability in embryonic development and stem cell function, Nat Rev Mol Cell Biol, vol.9, pp.285-96, 2008.

U. Testa and R. Riccioni, Deregulation of apoptosis in acute myeloid leukemia, Haematologica, vol.92, pp.81-94, 2007.

N. Chetoui, K. Sylla, J. Gagnon-houde, C. Alcaide-loridan, D. Charron et al., Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis, Mol Cancer Res MCR, vol.6, pp.42-52, 2008.
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P. Obexer and M. J. Ausserlechner, X-linked inhibitor of apoptosis protein -a critical death resistance regulator and therapeutic target for personalized cancer therapy, Front Oncol, vol.4, p.197, 2014.

I. Tamm, S. M. Kornblau, H. Segall, S. Krajewski, K. Welsh et al., Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias, Clin Cancer Res Off J Am Assoc Cancer Res, vol.6, pp.1796-803, 2000.

Z. Dong, M. A. Venkatachalam, J. Wang, Y. Patel, P. Saikumar et al., Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms, J Biol Chem, vol.276, pp.18702-18711, 2001.

K. L. Jin, X. O. Mao, T. Nagayama, P. C. Goldsmith, and D. A. Greenberg, Induction of vascular endothelial growth factor and hypoxia-inducible factore-1alpha by global ischemia in rat brain, Neurosc, vol.99, pp.577-85, 2000.