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Journal articles

"Laparoscopic Para-Aortic Lymph Node Sampling” First Approach for Pancreatic Adenocarcinoma as an Oncological Practice

Abstract : Background: In the setting of pancreatic ductal adenocarcinoma (PDAC), para-aortic lymph node (PALN) involvement is considered as a metastasis disease. To date, no morphological examination can effectively identify lymph node metastasis, and a significant number of patients undergo futile invasive laparotomy for PALN involvement. From an oncological point of view, laparoscopy represents a better approach for PALN sampling. The main aim of the study is to propose a laparoscopic PALN sampling first approach. We describe the surgical technique and demonstrate its technical feasibility as a routine approach as the first surgical step before pancreaticoduodenectomy for localized PDAC. Materials and Methods: During a first step of staging laparoscopy, PALN sampling was done for 31 patients with localized PDAC between November 2015 and February 2017. Demographic data and intraoperative, postoperative, and pathological criteria were evaluated. The surgical technique is described in detail. Results: The median operative time was 35 (range 18–65) minutes. The median number of PALN analyzed per patient was 2 (range 1–5). Four (13%) of 31 patients had positive PALN in frozen section analysis. No severe complication was reported for patients with positive PALN, receiving laparoscopic exploration and PALN sampling. The median hospital stay for patients with positive PALN was 2 (range 1–7) days. Conclusion: To avoid futile laparotomy, a staging laparoscopy is usually carried out. We report the feasibility and safety of laparoscopic PALN sampling and suggest its systematic realization during staging laparoscopy as a first step in patients with localized PDAC before pancreaticoduodenectomy.
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Journal articles
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Submitted on : Tuesday, November 19, 2019 - 3:07:30 PM
Last modification on : Wednesday, April 6, 2022 - 5:04:02 PM



Lilian Schwarz, Pauline Tortajada, Gabriella Pittau, Frédéric Di Fiore, David Sefrioui, et al.. "Laparoscopic Para-Aortic Lymph Node Sampling” First Approach for Pancreatic Adenocarcinoma as an Oncological Practice. Journal of Laparoendoscopic and Advanced Surgical Techniques, Mary Ann Liebert, 2019, 29 (7), pp.900-904. ⟨10.1089/lap.2018.0775⟩. ⟨hal-02370649⟩



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