Practical Synthesis of Ethyl 3-Fluoro-1-pyrrole-2-carboxylate: A Key Fragment of a Potent Drug Candidate against Hepatitis B Virus - Normandie Université Access content directly
Journal Articles Organic Process Research and Development Year : 2019

Practical Synthesis of Ethyl 3-Fluoro-1-pyrrole-2-carboxylate: A Key Fragment of a Potent Drug Candidate against Hepatitis B Virus

Adeline René
  • Function : Author
Maxime Quilan
  • Function : Author
Yicheng Deng
  • Function : Author
Yang Cheng
  • Function : Author
Christopher Teleha
  • Function : Author
Pierre Raboisson
  • Function : Author
Jean-François Bonfanti
  • Function : Author
Jérôme Fortin
  • Function : Author
André. Charette
  • Function : Author

Abstract

We report herein the development of two efficient synthetic routes for the preparation of a key fragment required for the synthesis of potent drug candidates of Hepatitis B virus. The ethyl 3-fluoro-1-H-pyrrole-2-carboxylate scaffold was synthesized from readily available starting materials in good overall yields. The scalability of one of the developed routes was demonstrated and afforded the desired target in good yield and excellent purity (99%).
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Dates and versions

hal-02364011 , version 1 (14-11-2019)

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Adeline René, Maxime Quilan, Yicheng Deng, Yang Cheng, Christopher Teleha, et al.. Practical Synthesis of Ethyl 3-Fluoro-1-pyrrole-2-carboxylate: A Key Fragment of a Potent Drug Candidate against Hepatitis B Virus. Organic Process Research and Development, 2019, 24 (5), pp.792-801. ⟨10.1021/acs.oprd.9b00382⟩. ⟨hal-02364011⟩
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