Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors

Yvonnick Loidreau (1) , Pascal Marchand (2) , Carole Dubouilh-Benard (1) , Marie-Renée Nourrisson (2) , Muriel Duflos (2) , Olivier Lozach (3) , Nadège Loaëc (4) , Laurent Meijer (3) , Thierry Besson (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 IICiMed - Cibles et Médicaments des Infections et de l'Immunité
3 SBR - Station biologique de Roscoff
4 ManRos Therapeutics

Domains: Chemical Sciences; Organic chemistry; Chemical Sciences; Analytical chemistry; Chemical Sciences; Catalysis; Chemical Sciences; Medicinal Chemistry

Yvonnick Loidreau, Pascal Marchand, Carole Dubouilh-Benard, Marie-Renée Nourrisson, Muriel Duflos, et al.. Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors. European Journal of Medicinal Chemistry, 2012, 58, pp.171-183. ⟨10.1016/j.ejmech.2012.10.006⟩. ⟨hal-02357785⟩