Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: Synthesis, biological evaluation and molecular modeling studies

Cédric Logé (1) , Alexandra Testard (2) , Valérie Thiéry (2) , Olivier Lozach (3) , Mélina Blairvacq (3) , Jean-Michel Robert (1) , Laurent Meijer (3) , Thierry Besson (2)

1 IICiMed - Cibles et Médicaments des Infections et de l'Immunité
2 LGPC - Laboratoire de Génie Protéique et Cellulaire
3 SBR - Station biologique de Roscoff = Roscoff Marine Station

Domaines: Chimie organique; Chimie analytique; Catalyse; Chimie thérapeutique

Cédric Logé, Alexandra Testard, Valérie Thiéry, Olivier Lozach, Mélina Blairvacq, et al.. Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: Synthesis, biological evaluation and molecular modeling studies. European Journal of Medicinal Chemistry, 2008, 43 (7), pp.1469-1477. ⟨10.1016/j.ejmech.2007.09.020⟩. ⟨hal-02357774⟩